ULTRASOUND-MEDIATED TARGETED DRUG DELIVERY GENERATED BY MULTIFOCAL BEAM PATTERNS: AN IN VITRO STUDY

被引：13

作者：

Gourevich, Dana ^{[1
,2
]}

Hertzberg, Yoni ^{[3
]}

Volovick, Alexander ^{[1
,4
]}

Shafran, Yaron ^{[4
]}

Navon, Gil ^{[3
]}

Cochran, Sandy ^{[1
]}

Melzer, Andreas ^{[1
]}

机构：

[1] Univ Dundee, Inst Med Sci & Technol, Dundee DD2 1FD, Scotland

[2] Capsutech Ltd, Nazareth, Israel

[3] Tel Aviv Univ, IL-69978 Tel Aviv, Israel

[4] InSightec Ltd, Haifa, Israel

来源：

ULTRASOUND IN MEDICINE AND BIOLOGY | 2013年 / 39卷 / 03期

关键词：

Targeted drug delivery; Focused ultrasound; Multifocus beam patterns; Microbubbles; Cancer cell lines; CELLS;

D O I：

10.1016/j.ultrasmedbio.2012.10.013

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

Ultrasound-mediated targeted drug delivery has been a subject for a dedicated research activity for several decades. Nevertheless, in vitro studies in this field of research are characterized by their inconsistencies. To improve the repeatability of such experiments, a novel approach of multifocal spot generation was investigated. A multifocal pattern of 16 spots was utilized using an iterative Gerchberg-Saxton algorithm. The pattern was applied to insonate a 96-well Petri dish plate using a clinically available planar-phased array transducer with approximately 1000 elements with a central frequency of 0.55 MHz. The pattern was acoustically characterized and applied to a monolayer of human breast cancer cell line in the 96-well plate. With the help of ultrasonic contrast agents, the intracellular drug uptake was increased by an average factor of 3.5 compared with the control group. (E-mail: a.volovyk@dundee.ac.uk) (C) 2013 World Federation for Ultrasound in Medicine & Biology.

引用

页码：507 / 514

页数：8

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