Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease

被引：50

作者：

Hippen, Keli L. ^{[1
]}

Loschi, Michael ^{[1
]}

Nicholls, Jemma ^{[1
]}

MacDonald, Kelli P. A. ^{[2
,3
]}

Blazar, Bruce R. ^{[1
]}

机构：

[1] Univ Minnesota, Dept Pediat, Canc Ctr, Div Blood & Marrow Transplantat, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Canc Ctr, QIMR Berghofer Med Res Inst, Antigen Presentat & Immunoregulat Lab, Brisbane, Qld, Australia

[3] Univ Minnesota, Canc Ctr, QIMR Berghofer Med Res Inst, Bone Marrow Transplantat Lab, Brisbane, Qld, Australia

来源：

FRONTIERS IN IMMUNOLOGY | 2018年 / 9卷

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

regulatory T cell; tTreg; iTreg; microRNA; graft-versus-host disease; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; TRANSCRIPTION FACTOR; SUPPRESSIVE FUNCTION; MEDIATED REGULATION; FOXP3; EXPRESSION; MESSENGER-RNA; TH1; RESPONSES; TARGET GENES; DIFFERENTIATION; PLASTICITY;

D O I：

10.3389/fimmu.2018.00057

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Regulatory T cells (Tregs) are key mediators of the immune system. MicroRNAs (miRNAs) are a family of similar to 22 nucleotide non-coding RNAs that are processed from longer precursors by the RNases Drosha and Dicer. miRNA regulates protein expression posttran-scriptionally through mRNA destabilization or translational silencing. A critical role for miRNA in Treg function was initially discovered when both Dicer and Drosha knockout (KO) mice were found to develop a fatal autoimmune disease phenotypically similar to Foxp3 KO mice.

引用

页数：7

共 73 条

[1]

[Anonymous], BLOOD

[2] MicroRNA-mediated regulation of T helper cell differentiation and plasticity [J].

Baumjohann, Dirk ;

Ansel, K. Mark .

NATURE REVIEWS IMMUNOLOGY, 2013, 13 (09) :666-678

[3] MicroRNA control of lymphocyte differentiation and function [J].

Belver, Laura ;

Papavasiliou, F. Nina ;

Ramiro, Almudena R. .

CURRENT OPINION IN IMMUNOLOGY, 2011, 23 (03) :368-373

[4] All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation [J].

Benson, Micah J. ;

Pino-Lagos, Karina ;

Rosemblatt, Mario ;

Noelle, Randolph J. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (08) :1765-1774

[5] Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation [J].

Beyer, Marc ;

Thabet, Yasser ;

Mueller, Roman-Ulrich ;

Sadlon, Timothy ;

Classen, Sabine ;

Lahl, Katharina ;

Basu, Samik ;

Zhou, Xuyu ;

Bailey-Bucktrout, Samantha L. ;

Krebs, Wolfgang ;

Schoenfeld, Eva A. ;

Boettcher, Jan ;

Golovina, Tatiana ;

Mayer, Christian T. ;

Hofmann, Andrea ;

Sommer, Daniel ;

Debey-Pascher, Svenja ;

Endl, Elmar ;

Limmer, Andreas ;

Hippen, Keli L. ;

Blazar, Bruce R. ;

Balderas, Robert ;

Quast, Thomas ;

Waha, Andreas ;

Mayer, Guenter ;

Famulok, Michael ;

Knolle, Percy A. ;

Wickenhauser, Claudia ;

Kolanus, Waldemar ;

Schermer, Bernhard ;

Bluestone, Jeffrey A. ;

Barry, Simon C. ;

Sparwasser, Tim ;

Riley, James L. ;

Schultze, Joachim L. .

NATURE IMMUNOLOGY, 2011, 12 (09) :898-U125

[6] Transcriptome profiling of human FoxP3+ regulatory T cells [J].

Bhairavabhotla, Ravikiran ;

Kim, Yong C. ;

Glass, Deborah D. ;

Escobar, Thelma M. ;

Patel, Mira C. ;

Zahr, Rami ;

Nguyen, Cuong K. ;

Kilaru, Gokhul K. ;

Muljo, Stefan A. ;

Shevach, Ethan M. .

HUMAN IMMUNOLOGY, 2016, 77 (02) :201-213

[7] Advances in graft-versus-host disease biology and therapy [J].

Blazar, Bruce R. ;

Murphy, William J. ;

Abedi, Mehrdad .

NATURE REVIEWS IMMUNOLOGY, 2012, 12 (06) :443-458

[8] Type 1 diabetes immunotherapy using polyclonal regulatory T cells [J].

Bluestone, Jeffrey A. ;

Buckner, Jane H. ;

Fitch, Mark ;

Gitelman, Stephen E. ;

Gupta, Shipra ;

Hellerstein, Marc K. ;

Herold, Kevan C. ;

Lares, Angela ;

Lee, Michael R. ;

Li, Kelvin ;

Liu, Weihong ;

Long, S. Alice ;

Masiello, Lisa M. ;

Vinh Nguyen ;

Putnam, Amy L. ;

Rieck, Mary ;

Sayre, Peter H. ;

Tang, Qizhi .

SCIENCE TRANSLATIONAL MEDICINE, 2015, 7 (315)

[9] T Regulatory Cells in Autoimmune Diabetes: Past Challenges, Future Prospects [J].

Bluestone, Jeffrey A. ;

Tang, Qizhi ;

Sedwick, Caitlin E. .

JOURNAL OF CLINICAL IMMUNOLOGY, 2008, 28 (06) :677-684

[10] Umbilical cord blood-derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect [J].

Brunstein, Claudio G. ;

Miller, Jeffrey S. ;

McKenna, David H. ;

Hippen, Keli L. ;

Defor, Todd E. ;

Sumstad, Darin ;

Curtsinger, Julie ;

Verneris, Michael R. ;

MacMillan, Margaret L. ;

Levine, Bruce L. ;

Riley, James L. ;

June, Carl H. ;

Le, Chap ;

Weisdorf, Daniel J. ;

McGlave, Philip B. ;

Blazar, Bruce R. ;

Wagner, John E. .

BLOOD, 2016, 127 (08) :1044-1051

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