Design and synthesis of a fluorescent amino poly(glycidyl methacrylate) for efficient gene delivery

被引：5
作者：
Chen, Hongtao [1 ]
You, Shusen [1 ]
Cai, Qing [1 ]
Zheng, Yang [2 ]
Zhang, Liqun [1 ]
Shen, Jie [2 ]
Yin, Meizhen [1 ]
机构：
[1] Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing Adv Innovat Ctr Soft Matter Sci & Engn, BAIC SM,Beijing Lab Biomed Mat, Beijing 100029, Peoples R China
[2] China Agr Univ, Dept Entomol, Beijing 100193, Peoples R China
来源：
JOURNAL OF MATERIALS CHEMISTRY B | 2019年 / 7卷 / 11期
基金：
中国国家自然科学基金; 北京市自然科学基金;
关键词：
DENDRIMERS; TRANSFECTION; PDMAEMA;
D O I：
10.1039/c8tb02968g
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
A fluorescent amino poly(glycidyl methacrylate) (PGOHMA) was synthesized by atom transfer radical polymerization (ATRP) and post-polymerization. The obtained star polymer PGOHMA has eight polymer arms enriched with amine groups for gene delivery. PGOHMA showed much lower cytotoxicity and higher delivery efficiency, compared with the widely used commercial and previously reported gene carriers. Therefore, a new star-shaped fluorescent polymer was successfully synthesized and explored as an efficient gene carrier.
引用
收藏
页码：1875 / 1881
页数：7
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