Synthesis of 2-substituted indoles by iridium (III)-catalyzed C-H functionalization of N-phenylpyridin-2-amines

被引：31

作者：

Zhang, Lei ^{[1
]}

Chen, Junyu ^{[1
]}

Chen, Jinkang ^{[1
]}

Jin, Licheng ^{[1
]}

Zheng, Xiangyun ^{[1
]}

Jiang, Xinpeng ^{[1
]}

Yu, Chuanming ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China

来源：

TETRAHEDRON LETTERS | 2019年 / 60卷 / 15期

基金：

中国国家自然科学基金;

关键词：

Iridium; Sulfoxonium ylides; C-H functionalization; Indole; SULFOXONIUM YLIDES; ACTIVATION; CYCLIZATION; AMIDATION; AMINATION; ANILINES; ACYLMETHYLATION; ALLYLATION; ANNULATION; ARYLATION;

D O I：

10.1016/j.tetlet.2019.03.027

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly regioselective synthesis of 2-substituted indoles was realized through Ir(III)-catalyzed C-H functionalization of N-phenylpyridin-2-amines followed by the reaction with sulfoxonium ylides and intramolecular cyclization under mild conditions. The reaction completed with broad range of substrate scopes and gave various 2-substituted indoles in up to 98% yields. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：1053 / 1056

页数：4

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