Heat-epimerized tea catechins have the same cholesterol-lowering activity as green tea catechins in cholesterol-fed rats

被引：40

作者：

Kobayashi, M ^{[1
]}

Unno, T

Suzuki, Y

Nozawa, A

Sagesaka, Y

Kakuda, T

Ikeda, I

机构：

[1] Ito En Ltd, Cent Res Inst, Shizuoka 4210516, Japan

[2] Tohoku Univ, Grad Sch Agr Sci, Dept Food Funct & Hlth, Lab Food & Biomol Sci, Sendai, Miyagi 9818555, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2005年 / 69卷 / 12期

关键词：

tea catechins; heat-epimerized tea catechins; cholesterol; rats;

D O I：

10.1271/bbb.69.2455

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tea catechins are known to be epimerized by heat treatment. The effect of heat-epimerized tea catechins on serum cholesterol concentration was compared with that of green tea catechins. Our observations strongly suggest that both tea catechins and heat-epimerized tea catechins lower serum cholesterol concentration by inhibiting cholesterol absorption in the intestine. There was no differential effect between the two catechin preparations.

引用

收藏

页码：2455 / 2458

页数：4

相关论文

共 20 条

[1] Green tea polyphenols: Novel and potent inhibitors of squalene epoxidase [J].

Abe, I ;

Seki, T ;

Umehara, K ;

Miyase, T ;

Noguchi, H ;

Sakakibara, J ;

Ono, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 268 (03) :767-771

[2] Jasmine green tea epicatechins are hypolipidemic in hamsters (Mesocricetus auratus) fed a high fat diet [J].

Chan, PT ;

Fong, WP ;

Cheung, YL ;

Huang, Y ;

Ho, WKK ;

Chen, ZY .

JOURNAL OF NUTRITION, 1999, 129 (06) :1094-1101

[3] Degradation of green tea catechins in tea drinks [J].

Chen, ZY ;

Zhu, QY ;

Tsang, D ;

Huang, Y .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2001, 49 (01) :477-482

[4]

FOLCH J, 1957, J BIOL CHEM, V226, P497

[5] Cancer inhibition by green tea [J].

Fujiki, H ;

Suganuma, M ;

Okabe, S ;

Sueoka, N ;

Komori, A ;

Sueoka, E ;

Kozu, T ;

Tada, Y ;

Suga, K ;

Imai, K ;

Nakachi, K .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 1998, 402 (1-2) :307-310

[6] TEA CATECHINS DECREASE MICELLAR SOLUBILITY AND INTESTINAL-ABSORPTION OF CHOLESTEROL IN RATS [J].

IKEDA, I ;

IMASATO, Y ;

SASAKI, E ;

NAKAYAMA, M ;

NAGAO, H ;

TAKEO, T ;

YAYABE, E ;

SUGANO, M .

BIOCHIMICA ET BIOPHYSICA ACTA, 1992, 1127 (02) :141-146

[7] Heat-epimerized tea catechins rich in gallocatechin gallate and catechin gallate are more effective to inhibit cholesterol absorption than tea catechins rich in epigallocatechin gallate and epicatechin gallate [J].

Ikeda, I ;

Kobayashi, M ;

Hamada, T ;

Tsuda, K ;

Goto, H ;

Imaizumi, K ;

Nozawa, A ;

Sugimoto, A ;

Kakuda, T .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2003, 51 (25) :7303-7307

[8] ALPHA-LINOLENIC, EICOSAPENTAENOIC AND DOCOSAHEXAENOIC ACIDS AFFECT LIPID-METABOLISM DIFFERENTLY IN RATS [J].

IKEDA, I ;

WAKAMATSU, K ;

INAYOSHI, A ;

IMAIZUMI, K ;

SUGANO, M ;

YAZAWA, K .

JOURNAL OF NUTRITION, 1994, 124 (10) :1898-1906

[9] CRUDE TEA EXTRACTS DECREASE THE MUTAGENIC ACTIVITY OF N-METHYL-N'-NITRO-N-NITROSOGUANIDINE INVITRO AND IN INTRAGASTRIC TRACT OF RATS [J].

JAIN, AK ;

SHIMOI, K ;

NAKAMURA, Y ;

KADA, T ;

HARA, Y ;

TOMITA, I .

MUTATION RESEARCH, 1989, 210 (01) :1-8

[10]

Kajimoto O, 2003, J CLIN BIOCHEM NUTR, V33, P101