Progress and challenges in the adjuvant treatment of stage II and III colon cancers

被引：24

作者：

Chua, Yu Jo ^{[2
]}

Zalcberg, John R. ^{[1
]}

机构：

[1] Peter MacCallum Canc Inst, Div Haematol & Med Oncol, Melbourne, Vic 8006, Australia

[2] Canberra Hosp, Canberra, ACT, Australia

来源：

EXPERT REVIEW OF ANTICANCER THERAPY | 2008年 / 8卷 / 04期

关键词：

adjuvant chemotherapy; capecitabine; colon cancer; disease-free survival; fluorouracil; leucovorin; oxaliplatin; prognostic factors;

D O I：

10.1586/14737140.8.4.595

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Whereas the benefit of adjuvant 5-fluorouracil and leucovorin have been well established in resected stage III colon cancer, a significant benefit for patients with stage 11 disease has been more difficult to demonstrate. More recently, oxaliplatin-based chemotherapy with regimens such as oxaplatin plus 5-fluorouracil/leucovorin have been shown to improve disease-free and overall survival in these stage III patients. This review will discuss the development of adjuvant chemotherapy in colon cancer, focusing on recent progress and particular topical issues related to its use in this disease, such as the use of surrogate end points for overall survival in contemporary clinical trials.

引用

页码：595 / 604

页数：10

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