Non-coding RNAs in hepatitis B or C-associated hepatocellular carcinoma: Potential diagnostic and prognostic markers and therapeutic targets

被引：30

作者：

Zhang, Qi ^{[1
]}

Pu, Rui ^{[1
]}

Du, Yan ^{[1
]}

Han, Yifang ^{[1
]}

Su, Tong ^{[1
]}

Wang, Hongyang ^{[2
]}

Cao, Guangwen ^{[1
]}

机构：

[1] Second Mil Med Univ, Shanghai Key Lab Med Biodef, Dept Epidemiol, Shanghai 200433, Peoples R China

[2] Eastern Hepatobiliary Surg Inst Hosp, Int Cooperat Lab Signal Transduct, Shanghai, Peoples R China

来源：

CANCER LETTERS | 2012年 / 321卷 / 01期

关键词：

Hepatitis virus; Hepatocellular carcinoma; Non-coding RNA; Biomarker; Therapeutic target; VIRUS X PROTEIN; REGULATES G(1)/S TRANSITION; MICRORNA EXPRESSION; LIVER-CANCER; FUNCTIONAL POLYMORPHISM; CELL-PROLIFERATION; UP-REGULATION; DOXORUBICIN SENSITIVITY; TURKISH POPULATION; HEME OXYGENASE-1;

D O I：

10.1016/j.canlet.2012.03.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Non-coding RNA (ncRNA), a class of RNAs that do not code protein but have regulatory functions, can regulate gene expression and replication of hepatitis B virus or hepatitis C virus and play an important role in the virus-host interaction and the development of hepatocellular carcinoma (HCC). Deregulated ncRNAs in surgically removed hepatic tissues and circulation can be prognostic and diagnostic markers, respectively. ncRNAs functioning as either tumor suppressors or oncogenes can be therapeutic options. Here, we summarize the deregulated ncRNAs associated with the infections and HCC and focus on their roles on early diagnosis, prognosis prediction and therapeutic option of HCC. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

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页码：1 / 12

页数：12

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