WNT secretion and signalling in human disease

被引：147

作者：

Herr, Patrick ^{[1
]}

Hausmann, George ^{[1
]}

Basler, Konrad ^{[1
]}

机构：

[1] Univ Zurich, Inst Mol Life Sci, CH-8057 Zurich, Switzerland

来源：

TRENDS IN MOLECULAR MEDICINE | 2012年 / 18卷 / 08期

基金：

瑞士国家科学基金会;

关键词：

INTESTINAL EPITHELIAL-CELLS; INFLAMMATORY-BOWEL-DISEASE; FRIZZLED-RELATED PROTEINS; FOCAL DERMAL HYPOPLASIA; HUMAN CANCER-CELLS; BREAST-CANCER; LIPOPROTEIN PARTICLES; ESOPHAGEAL CANCER; PARKINSON DISEASE; TUMOR-SUPPRESSOR;

D O I：

10.1016/j.molmed.2012.06.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Wnt signalling, a key pathway involved in various aspects of embryonic development, also underlies many human diseases, in particular, cancer. Research focused on signal transduction within signal-receiving cells led to the discovery of many Wnt pathway components, but study of the secretion of Wnt ligands themselves was neglected until recently. Attention was drawn to this highly regulated process by the association of aberrant Wnt levels with an increasing number of diseases. Studying the biogenesis and processing of active Wnt ligands will open new avenues for generating therapeutics to specifically target aberrant Wnt signalling. Here we review the proteins required for Wnt secretion and signalling at the plasma membrane, ending with a discussion on potential therapeutic approaches to treat Wnt-induced diseases.

引用

页码：483 / 493

页数：11

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