Effects of Antifungal Agents Alone and in Combination Against Candida glabrata Strains Susceptible or Resistant to Fluconazole

被引：18

作者：

Alves, Izabel Almeida ^{[1
]}

Bandeira, Laissa Arevalo ^{[1
]}

Nunes Mario, Debora Alves ^{[1
]}

Denardi, Laura Bedin ^{[1
]}

Neves, Louise Vignoles ^{[1
]}

Santurio, Janio Morais ^{[1
]}

Alves, Sydney Hartz ^{[1
]}

机构：

[1] Univ Fed Santa Maria, Dept Microbiol & Parasitol, BR-97010033 Santa Maria, RS, Brazil

来源：

MYCOPATHOLOGIA | 2012年 / 174卷 / 03期

关键词：

Candida glabrata; Resistance; Antifungal drug combination; IN-VITRO ACTIVITIES; AMPHOTERICIN-B; AZOLE RESISTANCE; TIME-KILL; VORICONAZOLE; CASPOFUNGIN; THERAPY; 5-FLUOROCYTOSINE; EPIDEMIOLOGY; SURVEILLANCE;

D O I：

10.1007/s11046-012-9538-7

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The rise of Candida spp. resistant to classic triazole antifungal agents has led to a search for new therapeutic options. Here, we evaluated combinations of antifungals in a checkerboard assay against two groups of Candida glabrata strains: one containing fluconazole-susceptible clinical isolates (FS) and another containing fluconazole-resistant laboratory derivative (FR). The most synergistic combination observed was amphotericin B + flucytosine (synergistic for 61.77 % of FS strains and 76.47 % of FR strains). The most antagonistic combination observed was ketoconazole + flucytosine (FS 61.77 % and FR 55.88 %). Surprisingly, most combinations evidenced indifferent interactions, and the best synergism appeared when amphotericin B and flucytosine were combined against both groups of isolates.

引用

页码：215 / 221

页数：7

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