Effects of Antifungal Agents Alone and in Combination Against Candida glabrata Strains Susceptible or Resistant to Fluconazole

被引：18
作者：
Alves, Izabel Almeida [1 ]
Bandeira, Laissa Arevalo [1 ]
Nunes Mario, Debora Alves [1 ]
Denardi, Laura Bedin [1 ]
Neves, Louise Vignoles [1 ]
Santurio, Janio Morais [1 ]
Alves, Sydney Hartz [1 ]
机构：
[1] Univ Fed Santa Maria, Dept Microbiol & Parasitol, BR-97010033 Santa Maria, RS, Brazil
来源：
MYCOPATHOLOGIA | 2012年 / 174卷 / 03期
关键词：
Candida glabrata; Resistance; Antifungal drug combination; IN-VITRO ACTIVITIES; AMPHOTERICIN-B; AZOLE RESISTANCE; TIME-KILL; VORICONAZOLE; CASPOFUNGIN; THERAPY; 5-FLUOROCYTOSINE; EPIDEMIOLOGY; SURVEILLANCE;
D O I：
10.1007/s11046-012-9538-7
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The rise of Candida spp. resistant to classic triazole antifungal agents has led to a search for new therapeutic options. Here, we evaluated combinations of antifungals in a checkerboard assay against two groups of Candida glabrata strains: one containing fluconazole-susceptible clinical isolates (FS) and another containing fluconazole-resistant laboratory derivative (FR). The most synergistic combination observed was amphotericin B + flucytosine (synergistic for 61.77 % of FS strains and 76.47 % of FR strains). The most antagonistic combination observed was ketoconazole + flucytosine (FS 61.77 % and FR 55.88 %). Surprisingly, most combinations evidenced indifferent interactions, and the best synergism appeared when amphotericin B and flucytosine were combined against both groups of isolates.
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页码：215 / 221
页数：7
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