New developments on the role of NMDA receptors in Alzheimer's disease

被引：105

作者：

Malinow, Roberto ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Dept Neurosci, Ctr Neural Circuits & Behav, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Ctr Neural Circuits & Behav, Div Biol, La Jolla, CA 92093 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2012年 / 22卷 / 03期

关键词：

AMYLOID PRECURSOR PROTEIN; LONG-TERM POTENTIATION; DENDRITIC SPINE LOSS; IN-VIVO; BETA PROTEIN; SYNAPTIC PLASTICITY; MOUSE MODELS; SIGNALING PATHWAY; TRANSGENIC MICE; OLIGOMERS;

D O I：

10.1016/j.conb.2011.09.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Since the initial findings that NMDA receptors play important roles in cellular models of learning as well as neurotoxicity, abnormal function of this receptor has been considered a potential mechanism in the pathophysiology underlying Alzheimer's disease. Treatment of Alzheimer's disease with an NMDA receptor antagonist began several years ago, with some limited success. More recent mechanistic studies have examined the role of NMDA receptors in the synaptic effects of beta amyloid (A beta).

引用

页码：559 / 563

页数：5

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