Levetiracetam May Worsen Myoclonus in Patients With Juvenile Myoclonic Epilepsy: Case Reports

被引：8
|
作者：
Babtain, Fawzi A. [1 ]
机构：
[1] King Khalid Univ, Div Neurol, Assir Cent Hosp, Abha 61421, Saudi Arabia
来源：
CLINICAL NEUROPHARMACOLOGY | 2012年 / 35卷 / 04期
关键词：
levetiracetam; juvenile myoclonus epilepsy; myoclonus; paradoxical response; IDIOPATHIC GENERALIZED EPILEPSY; PLACEBO-CONTROLLED TRIAL; SEIZURES;
D O I：
10.1097/WNF.0b013e31825eed8c
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Levetiracetam was approved for generalized and partial epilepsy in pediatric and adult population. It is also an effective antimyoclonus, but the evidence only supports its use as an adjunctive agent along with other antiepileptic drugs, such as sodium valproate, and it is commonly used in cases with juvenile myoclonic epilepsy. We report here 2 cases with juvenile myoclonic epilepsy who were switched from sodium valproate to levetiracetam to avoid the cosmetic or future teratogenic effect, but this switch was associated with exaggerated myoclonus despite escalating the dose of levetiracetam but resolved completely after reintroducing sodium valproate.
引用
收藏
页码：201 / 202
页数：2
相关论文
共 50 条
  • [21] Cognitive performance in juvenile myoclonic epilepsy patients with specific endophenotypes
    de Carvalho, Kelly Cristina
    Pedroso Uchida, Carina Goncalves
    Bittar Guaranha, Mirian Salvadori
    Guilhoto, Laura Maria F. F.
    Wolf, Peter
    Targas Yacubian, Elza Marcia
    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2016, 40 : 33 - 41
  • [22] Myoclonus improvement after seizures in progressive myoclonic epilepsy type 7: a case report
    Lima, Pedro Lucas G. S. B.
    Nobrega, Paulo R.
    Freua, Fernando
    Braga-Neto, Pedro
    Paiva, Anderson R. B.
    Guimaraes, Thiago Goncalves
    Kok, Fernando
    BMC NEUROLOGY, 2024, 24 (01)
  • [23] Psychiatric disorders in juvenile myoclonic epilepsy:: A controlled study of 100 patients
    de Araujo Filho, Gerardo Maria
    Pascalicchio, Tatiana F.
    da Silva Sousa, Patricia
    Lin, Katia
    Guilhoto, Laura M. F. Ferreira
    Yacubian, Elza Marcia T.
    EPILEPSY & BEHAVIOR, 2007, 10 (03) : 437 - 441
  • [24] Treatment of Juvenile Myoclonic Epilepsy in Patients of Child-Bearing Potential
    Serafini, Anna
    Gerard, Elizabeth
    Genton, Pierre
    Crespel, Arielle
    Gelisse, Philippe
    CNS DRUGS, 2019, 33 (03) : 195 - 208
  • [25] Nonconvulsion status epilepticus in patients with juvenile myoclonic epilepsy:: types and frequencies
    Dziewas, R
    Kellinghaus, C
    Lüdemann, P
    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2002, 11 (05): : 335 - 339
  • [26] Neuropsychological profiles of patients with juvenile myoclonic epilepsy and their siblings: An extended study
    Iqbal, Nasur
    Caswell, Helen
    Muir, Robin
    Cadden, Amy
    Ferguson, Stuart
    Mackenzie, Holly
    Watson, Philip
    Duncan, Susan
    EPILEPSIA, 2015, 56 (08) : 1301 - 1308
  • [27] Epileptic discharges and phasic sleep phenomena in patients with juvenile myoclonic epilepsy
    Bonakis, Anastasios
    Koutroumanidis, Michalis
    EPILEPSIA, 2009, 50 (11) : 2434 - 2445
  • [28] Efficacy of levetiracetam, lamotrigine and sodium valproate on seizure attacks and EEG disorders in patients with juvenile myoclonic epilepsy: A double blind randomized clinical trial
    Daneshyar, Sajjad
    Ghiasian, Masoud
    Moradi, Sahar
    Khanlarzadeh, Elham
    CASPIAN JOURNAL OF INTERNAL MEDICINE, 2022, 13 (03) : 617 - 622
  • [29] Response to levetiracetam or lamotrigine in subjects with Juvenile Myoclonic Epilepsy previously treated with valproic acid: A single center retrospective study
    Milano, Chiara
    Turco, Francesco
    Pizzanelli, Chiara
    Bonanni, Enrica
    Siciliano, Gabriele
    Fornai, Francesco
    Giorgi, Filippo Sean
    EPILEPSY & BEHAVIOR, 2021, 115
  • [30] Juvenile myoclonic epilepsy may be a disorder of cortex rather than thalamus: An effective connectivity analysis
    Park, Kang Min
    Lee, Byung In
    Shin, Kyong Jin
    Ha, Sam Yeol
    Park, JinSe
    Kim, Si Eun
    Kim, Hyung Chan
    Kim, Tae Hyung
    Mun, Chi Woong
    Kim, Sung Eun
    JOURNAL OF CLINICAL NEUROSCIENCE, 2017, 35 : 127 - 132
12345