Levetiracetam May Worsen Myoclonus in Patients With Juvenile Myoclonic Epilepsy: Case Reports

被引：8

作者：

Babtain, Fawzi A. ^{[1
]}

机构：

[1] King Khalid Univ, Div Neurol, Assir Cent Hosp, Abha 61421, Saudi Arabia

来源：

CLINICAL NEUROPHARMACOLOGY | 2012年 / 35卷 / 04期

关键词：

levetiracetam; juvenile myoclonus epilepsy; myoclonus; paradoxical response; IDIOPATHIC GENERALIZED EPILEPSY; PLACEBO-CONTROLLED TRIAL; SEIZURES;

D O I：

10.1097/WNF.0b013e31825eed8c

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Levetiracetam was approved for generalized and partial epilepsy in pediatric and adult population. It is also an effective antimyoclonus, but the evidence only supports its use as an adjunctive agent along with other antiepileptic drugs, such as sodium valproate, and it is commonly used in cases with juvenile myoclonic epilepsy. We report here 2 cases with juvenile myoclonic epilepsy who were switched from sodium valproate to levetiracetam to avoid the cosmetic or future teratogenic effect, but this switch was associated with exaggerated myoclonus despite escalating the dose of levetiracetam but resolved completely after reintroducing sodium valproate.

引用

页码：201 / 202

页数：2

共 12 条

[1] Lacosamide treatment of juvenile myoclonic epilepsy [J].

Afra, Pegah ;

Adamolekun, Bola .

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2012, 21 (03) :202-204

[2] Placebo-controlled study of levetiracetam in idiopathic generalized epilepsy [J].

Berkovic, S. F. ;

Knowlton, R. C. ;

Leroy, R. F. ;

Schiemann, J. ;

Falter, U. .

NEUROLOGY, 2007, 69 (18) :1751-1760

[3] Dose-response effect of levetiracetam 1000 and 2000 mg/day in partial epilepsy [J].

Boon, P ;

Chauvel, P ;

Pohlmann-Eden, B ;

Otoul, C ;

Wroe, S .

EPILEPSY RESEARCH, 2002, 48 (1-2) :77-89

[4] Comparison of levetiracetam and controlled-release carbamazepine in newly diagnosed epilepsy [J].

Brodie, M. J. ;

Perucca, E. ;

Ryvlin, P. ;

Ben-Menachem, E. ;

Meencke, H. -J. .

NEUROLOGY, 2007, 68 (06) :402-408

[5] A multicenter, randomized, placebo-controlled trial of levetiracetam in children and adolescents with newly diagnosed absence epilepsy [J].

Fattore, Cinzia ;

Boniver, Clementina ;

Capovilla, Giuseppe ;

Cerminara, Caterina ;

Citterio, Antonietta ;

Coppola, Giangennaro ;

Costa, Paola ;

Darra, Francesca ;

Vecchi, Marilena ;

Perucca, Emilio .

EPILEPSIA, 2011, 52 (04) :802-809

[6] Double-blind placebo-controlled trial of adjunctive levetiracetam in pediatric partial seizures [J].

Glauser, T. A. ;

Ayala, R. ;

Elterman, R. D. ;

Mitchell, W. G. ;

Van Orman, C. B. ;

Gauer, L. J. ;

Lu, Z. .

NEUROLOGY, 2006, 66 (11) :1654-1660

[7] JUVENILE MYOCLONIC EPILEPSY - A REVIEW [J].

GRUNEWALD, RA ;

PANAYIOTOPOULOS, CP .

ARCHIVES OF NEUROLOGY, 1993, 50 (06) :594-598

[8] Practice Parameter update: Management issues for women with epilepsy-Focus on pregnancy (an evidence-based review): Obstetrical complications and change in seizure frequency Report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society [J].

Harden, C. L. ;

Hopp, J. ;

Ting, T. Y. ;

Pennell, P. B. ;

French, J. A. ;

Hauser, W. A. ;

Wiebe, S. ;

Gronseth, G. S. ;

Thurman, D. ;

Meador, K. J. ;

Koppel, B. S. ;

Kaplan, P. W. ;

Robinson, J. N. ;

Gidal, B. ;

Hovinga, C. A. ;

Wilner, A. N. ;

Vazquez, B. ;

Holmes, L. ;

Krumholz, A. ;

Finnell, R. ;

Le Guen, C. .

NEUROLOGY, 2009, 73 (02) :126-132

[9] SV2A protein is a broad-spectrum anticonvulsant target: Functional correlation between protein binding and seizure protection in models of both partial and generalized epilepsy [J].

Kaminski, Rafal M. ;

Matagne, Alain ;

Leclercq, Karine ;

Gillard, Michel ;

Michel, Philippe ;

Kenda, Benoit ;

Talaga, Patrice ;

Klitgaard, Henrik .

NEUROPHARMACOLOGY, 2008, 54 (04) :715-720

[10] Treatment Options in Juvenile Myoclonic Epilepsy [J].

Mantoan, Laura ;

Walker, Matthew .

CURRENT TREATMENT OPTIONS IN NEUROLOGY, 2011, 13 (04) :355-370

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