The Effects of Combined Treatment of Antioxidants on the Liver Injury in STZ Diabetic Rats

被引：33

作者：

Gezginci-Oktayoglu, Selda ^{[1
]}

Basaraner, Hasan ^{[2
]}

Yanardag, Refiye ^{[2
]}

Bolkent, Sehnaz ^{[1
]}

机构：

[1] Istanbul Univ, Dept Biol, Fac Sci, TR-34134 Istanbul, Turkey

[2] Istanbul Univ, Dept Chem, Fac Engn, TR-34320 Istanbul, Turkey

来源：

DIGESTIVE DISEASES AND SCIENCES | 2009年 / 54卷 / 03期

关键词：

Liver; STZ-diabetes; Selenium; Vitamin C; Vitamin E; LIPID-PEROXIDATION; OXIDATIVE STRESS; HEPATOTROPHIC FACTORS; BETA-CELLS; TISSUE; SUPPLEMENTATION; GLYCOSYLATION; COMPLICATIONS; GLUTATHIONE; METABOLISM;

D O I：

10.1007/s10620-008-0381-0

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The aim of this study was to examine whether an antioxidant combination of vitamin C, vitamin E, and sodium selenate (Se) has an effect on the liver of diabetic rats. Vitamin C, vitamin E, and Se were administered for 30 days to streptozotocin (STZ)-induced diabetic and control groups. In the STZ diabetic group, blood glucose levels, liver lipid peroxidation (LPO), and nonenzymatic glycosylation (NEG) levels increased, but blood and liver glutathione levels decreased. On the other hand, combined antioxidant treatment reversed these effects. In the diabetic group, some degenerative changes were observed by light and electron microscopic examinations, but the degenerative changes decreased in the diabetic group given antioxidant combination. Proliferating cell nuclear antigen (PCNA) immunohistochemistry showed that the number of proliferative hepatocytes increased significantly with antioxidant treatment. It was concluded that combined treatment with vitamin C, vitamin E, and Se has a curative effect against the hepatotoxicity produced by STZ-induced diabetes.

引用

页码：538 / 546

页数：9

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