Reaction of beta-cyclodextrin with N-2,3-epoxypropylphthalimide. Preparation, characterisation and study of a new substituted cycloheptaamylose. Effects on the water solubility of drugs

被引：3

作者：

Delgado, R

Virgili, A

GarciaAnton, JM

Parente, A

机构：

[1] UNIV AUTONOMA BARCELONA,DEPT QUIM,UNIT QUIM ORGAN,BELLATERRA 08193,BARCELONA,SPAIN

[2] LIPOTEC SA,BARCELONA 08902,SPAIN

来源：

JOURNAL OF INCLUSION PHENOMENA AND MOLECULAR RECOGNITION IN CHEMISTRY | 1997年 / 28卷 / 03期

关键词：

beta-cyclodextrin (beta-CD); epoxides; amorphous;

D O I：

10.1023/A:1007928520661

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reaction of beta-cyclodextrin with N-2,3-epoxypropylphthalimide yielded a set of new amorphous host compounds with high solubility which was transmitted to the corresponding host-guest complexes. The structure was determined by comparing the H-1- and C-13-NMR spectra with those of the parent compound, the degree of substitution by integration of the corresponding NMR signals, and C, H, and N elemental analysis.

引用

页码：205 / 212

页数：8

共 13 条

[11] ACCELERATION OF PHENYL ESTER CLEAVAGE BY CYCLOAMYLOSES - A MODEL FOR ENZYMATIC SPECIFICITY [J].