Reaction of beta-cyclodextrin with N-2,3-epoxypropylphthalimide. Preparation, characterisation and study of a new substituted cycloheptaamylose. Effects on the water solubility of drugs

被引：3

作者：

Delgado, R

Virgili, A

GarciaAnton, JM

Parente, A

机构：

[1] UNIV AUTONOMA BARCELONA,DEPT QUIM,UNIT QUIM ORGAN,BELLATERRA 08193,BARCELONA,SPAIN

[2] LIPOTEC SA,BARCELONA 08902,SPAIN

来源：

JOURNAL OF INCLUSION PHENOMENA AND MOLECULAR RECOGNITION IN CHEMISTRY | 1997年 / 28卷 / 03期

关键词：

beta-cyclodextrin (beta-CD); epoxides; amorphous;

D O I：

10.1023/A:1007928520661

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reaction of beta-cyclodextrin with N-2,3-epoxypropylphthalimide yielded a set of new amorphous host compounds with high solubility which was transmitted to the corresponding host-guest complexes. The structure was determined by comparing the H-1- and C-13-NMR spectra with those of the parent compound, the degree of substitution by integration of the corresponding NMR signals, and C, H, and N elemental analysis.

引用

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页码：205 / 212

页数：8

相关论文

共 13 条

[1] DRUG MEMBRANE-TRANSPORT ENHANCEMENT USING HIGH-ENERGY DRUG POLYVINYLPYRROLIDONE (PVP) CO-PRECIPITATES [J].

CORRIGAN, OI ;

FARVAR, MA ;

HIGUCHI, WI .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1980, 5 (03) :229-238

[2]

HEREDIA A, 1985, J CHEM SOC CHEM COMM, P1914

[3]

INOVE Y, 1979, B CHEM SOC JPN, V52, P1692

[4] SOLUTION GEOMETRY OF BETA-CYCLODEXTRIN-1-BROMOADAMANTANE HOST-GUEST COMPLEX AS DETERMINED BY H-1(H-1)-INTERMOLECULAR NOE AND MM2 CALCULATIONS [J].

JAIME, C ;

REDONDO, J ;

SANCHEZFERRANDO, F ;

VIRGILI, A .

JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (15) :4772-4776

[5] HYDROXYPROPYL-BETA-CYCLODEXTRIN - PREPARATION AND CHARACTERIZATION - EFFECTS ON SOLUBILITY OF DRUGS [J].

PITHA, J ;

MILECKI, J ;

FALES, H ;

PANNELL, L ;

UEKAMA, K .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1986, 29 (01) :73-82

[6] AMORPHOUS WATER-SOLUBLE DERIVATIVES OF CYCLODEXTRINS - NONTOXIC DISSOLUTION ENHANCING EXCIPIENTS [J].

PITHA, J ;

PITHA, J .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1985, 74 (09) :987-990

[7] SELF-ASSEMBLY OF CYCLODEXTRINS WITH MESO-TETRAKIS(4-SULFONATOPHENYL)PORPHYRIN IN AQUEOUS-SOLUTION [J].

RIBO, JM ;

FARRERA, JA ;

VALERO, ML ;

VIRGILI, A .

TETRAHEDRON, 1995, 51 (12) :3705-3712

[8] Host/guest interactions and NMR spectroscopy. A computer program for association constant determination [J].

Salvatierra, D ;

Diez, C ;

Jaime, C .

JOURNAL OF INCLUSION PHENOMENA AND MOLECULAR RECOGNITION IN CHEMISTRY, 1997, 27 (03) :215-231

[9]

Szejtli J., 1982, CYCLODEXTRINS THEIR

[10] ARTIFICIAL RECEPTORS FOR AMINO-ACIDS IN WATER - LOCAL ENVIRONMENTAL-EFFECT ON POLAR RECOGNITION BY 6A-AMINO-6B-CARBOXY-CYCLODEXTRINS AND 6B-AMINO-6A-CARBOXY-BETA-CYCLODEXTRINS [J].

TABUSHI, I ;

KURODA, Y ;

MIZUTANI, T .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (15) :4514-4518