Genetic Regulation of Atherosclerotic Plaque Size and Morphology in the Innominate Artery of Hyperlipidemic Mice

被引：15

作者：

Bennett, Brian J. ^{[1
]}

Wang, Susanna S. ^{[1
]}

Wang, Xuping ^{[1
]}

Wu, Xiaohui ^{[1
]}

Lusis, Aldons J. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Calif Los Angeles, Sch Med, Dept Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Sch Med, Dept Microbiol, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Sch Med, Dept Immunol, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, Sch Med, Dept Mol Genet, Los Angeles, CA 90095 USA

[5] Univ Calif Los Angeles, Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2009年 / 29卷 / 03期

关键词：

innominate artery; QTL; atherosclerosis; plaque stability; E-DEFICIENT MICE; DENSITY-LIPOPROTEIN LEVELS; TRAIT LOCUS ANALYSIS; SUSCEPTIBILITY LOCI; KNOCKOUT MOUSE; LESIONS; IDENTIFICATION; OSTEOPROTEGERIN; CALCIFICATION; EXPRESSION;

D O I：

10.1161/ATVBAHA.108.176685

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective-We sought to determine the genetic factors contributing to atherosclerotic plaque size and cellular composition in the innominate artery, a murine model of advanced atherosclerosis. Methods and Results-We examined genetic contributions to innominate atherosclerotic plaque size and cellular composition in an intercross between C57BL/6J.Apoe(-/-), a strain susceptible to aortic lesions, and C3H/HeJ.Apoe(-/-), a strain resistant to aortic lesions. Surprisingly, total innominate lesion size was similar in the two strains. Genetic analyses identified one novel locus on Chromosome 2 for innominate artery lesion size, a significant locus for fibrous cap thickness on Chromosome 15, and several suggestive loci for cellular composition, all distinct from loci influencing aortic lesions. The Chromosome 2 locus contains a candidate, CD44. We show that CD44 is expressed in the innominate artery and differs strikingly in expression between the parental strains. Conclusion-Multiple aspects of innominate lesion composition are genetically determined, but in a manner largely independent of the genetic contributions to aortic lesions. (Arterioscler Thromb Vasc Biol. 2009;29:348-355.)

引用

页码：348 / A18

页数：26

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