Overexpression of the transmembrane carbonic anhydrase isoforms IX and XII in the inflamed synovium

被引：81
|
作者：
Margheri, Francesca [1 ]
Ceruso, Mariangela [2 ]
Carta, Fabrizio [2 ]
Laurenzana, Anna [1 ]
Maggi, Laura [3 ]
Lazzeri, Simone [4 ,5 ]
Simonini, Gabriele [2 ,4 ,5 ]
Annunziato, Francesco [3 ]
Del Rosso, Mario [1 ]
Supuran, Claudiu T. [2 ]
Cimaz, Rolando [2 ,4 ,5 ]
机构：
[1] Univ Florence, Dept Expt & Clin Biomed Sci, Florence, Italy
[2] Univ Florence, Neurofarba Dept, Via U Schiff 6, I-50019 Florence, Italy
[3] Univ Florence, Dept Expt & Clin Med, Florence, Italy
[4] Anna Meyer Childrens Hosp, Florence, Italy
[5] Univ Florence, Viale Pieraccini 24, I-50139 Florence, Italy
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2016年 / 31卷
关键词：
Carbonic anhydrase; juvenile idiopathic arthritis; synovium; INHIBITORS; FLUID; PH;
D O I：
10.1080/14756366.2016.1217857
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Juvenile idiopathic arthritis (JIA) is the most common form of chronic rheumatic disease affecting children worldwide, with some features similar to adult rheumatoid arthritis (RA). In the present study, we aim at investigating novel markers that will allow in the future for tailored, more personalized treatment strategies. Hence, taking notice of several reports proving the role of local acidosis as a causal link between inflammatory diseases and related pain, and the involvement of several carbonic anhydrases (CA, EC 4.2.1.1) isoforms in articular diseases, we evaluated in JIA patients the expression of these metalloenzymes. We identified that JIA patients show high levels of active CA IX and XII isoforms. Our results represent the first evidence of the identification of these enzymes as potential therapeutic targets and development of novel innovative therapies for arthritis, also considering that the two isoforms are validated antitumor targets.
引用
收藏
页码：60 / 63
页数：4
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