Breast cancer manifested by hematologic disorders

被引：18

作者：

Ishikawa, Takashi ^{[1
]}

Shimizu, Daisuke ^{[1
]}

Kito, Ayako ^{[1
]}

Ota, Ikuko ^{[1
]}

Sasaki, Takeshi ^{[2
]}

Tanabe, Mikiko ^{[2
]}

Yamada, Akimitsu ^{[1
]}

Arioka, Hitoshi ^{[3
]}

Shimizu, Satoru ^{[4
]}

Wakasugi, Junichi ^{[5
]}

Mori, Ryutaro ^{[1
]}

Chishima, Takashi ^{[6
]}

Ichikawa, Yasushi ^{[6
]}

Endo, Itaru ^{[7
]}

机构：

[1] Yokohama City Univ, Med Ctr, Dept Breast & Thyroid Surg, Minami Ku, Yokohama, Kanagawa 2320024, Japan

[2] Yokohama City Univ, Med Ctr, Dept Pathol, Minami Ku, Yokohama, Kanagawa 2320024, Japan

[3] Yokohama Rosai Hosp, Div Med Oncol, Kohoku Ku, Yokohama, Kanagawa 2220036, Japan

[4] Kanagawa Canc Ctr, Div Breast & Thyroid Surg, Asahi Ku, Yokohama, Kanagawa 2410815, Japan

[5] Wakasugi Clin, Totsuka Ku, Yokohama, Kanagawa 2450061, Japan

[6] Yokohama City Univ, Grad Sch Med, Dept Clin Oncol, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan

[7] Yokohama City Univ, Grad Sch Med, Dept Surg Gastroenterol, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan

来源：

JOURNAL OF THORACIC DISEASE | 2012年 / 4卷 / 06期

关键词：

Breast cancer; disseminated intravascular coagulation; multiple organ metastases; THROMBOTIC THROMBOCYTOPENIC PURPURA; METASTASIS; TUMORS;

D O I：

10.3978/j.issn.2072-1439.2012.10.17

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Breast cancer is the most common type of cancer in women. However, it is very rarely manifested as hematologic disorders. A 35-year-old woman was admitted because of disseminated intravascular coagulation. Examinations revealed the presence of breast cancer in her left breast; therefore, paclitaxel was administered weekly. Although disseminated intravascular coagulation was controlled, pulmonary dysfunction due to lymphangitis carcinomatosa suddenly occurred 10 weeks after treatment. Pulmonary dysfunction was effectively treated with epirubicin and cyclophosphamide. Twenty-three weeks after treatment, the patient developed liver dysfunction accompanied with jaundice due to progressive metastatic lesions in the liver; liver dysfunction improved after the administration of vinorelbine. Subsequently, because of the recurrence of pulmonary dysfunction, rechallenge with epirubicin and cyclophosphamide was performed and was effective; however, this therapy was discontinued because of its adverse effects. She expired of liver failure 33 weeks after the occurrence of disseminated intravascular coagulation. Metastatic tumors in the bone marrow, lung, and liver showed different sensitivities to different anti-cancer agents. We report a case of breast cancer manifested by hematologic disorders which was treated by a sequential chemotherapy.

引用

页码：650 / 654

页数：5

共 11 条

[1] Thrombotic thrombocytopenic purpura associated with bone marrow metastasis and secondary myelofibrosis in cancer [J].