DNA-based asymmetric organometallic catalysis in water

被引：59
|
作者：
Oelerich, Jens [1 ]
Roelfes, Gerard [1 ]
机构：
[1] Univ Groningen, Stratingh Inst Chem, NL-9747 AG Groningen, Netherlands
来源：
CHEMICAL SCIENCE | 2013年 / 4卷 / 05期
关键词：
IN-SITU GENERATION; INTRAMOLECULAR CYCLOPROPANATION; COMPLEXES; ENANTIOSELECTIVITY; INTERCALATORS; HYDROCHLORIDE; PRINCIPLE; INSERTION; MIXTURES; LIGANDS;
D O I：
10.1039/c3sc00100h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Here, the first examples of DNA-based organometallic catalysis in water that give rise to high enantioselectivities are described. Copper complexes of strongly intercalating ligands were found to enable the asymmetric intramolecular cyclopropanation of alpha-diazo-beta-keto sulfones in water. Up to 84% ee was achieved, in the presence of salmon testes DNA as the only source of chirality, using dipyrido [3,2-a: 2',3'-c] phenazine (dppz) derivatives as ligands.
引用
收藏
页码：2013 / 2017
页数：5
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