Glioblastoma Resistance to Anti-VEGF Therapy: Has the Challenge Been MET?

被引：32

作者：

McCarty, Joseph H. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA

来源：

CLINICAL CANCER RESEARCH | 2013年 / 19卷 / 07期

关键词：

CANCER; ANGIOGENESIS; BEVACIZUMAB; INVASION; TUMORS;

D O I：

10.1158/1078-0432.CCR-13-0051

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In glioblastoma cells the receptor tyrosine kinase c-Met is upregulated in response to bevacizumab and plays an important role in promoting invasion and tumor recurrence. These data support novel links between VEGF-A and hepatocyte growth factor and suggest that c-Met and its signaling effectors may be effective targets for anti-invasive therapies. Clin Cancer Res; 19(7); 1631-3. (C) 2013 AACR.

引用

页码：1631 / 1633

页数：3

共 12 条

[1] Modes of resistance to anti-angiogenic therapy [J].

Bergers, Gabriele ;

Hanahan, Douglas .

NATURE REVIEWS CANCER, 2008, 8 (08) :592-603

[2] Met, metastasis, motility and more [J].

Birchmeier, C ;

Birchmeier, W ;

Gherardi, E ;

Vande Woude, GF .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (12) :915-925

[3] Tumor invasion after treatment of glioblastoma with bevacizumab: radiographic and pathologic correlation in humans and mice [J].

de Groot, John F. ;

Fuller, Gregory ;

Kumar, Ashok J. ;

Piao, Yuji ;

Eterovic, Karina ;

Ji, Yongjie ;

Conrad, Charles A. .

NEURO-ONCOLOGY, 2010, 12 (03) :233-242

[4] CANCER The nuances of therapy [J].

Ellis, Lee M. ;

Reardon, David A. .

NATURE, 2009, 458 (7236) :290-292

[5] Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer [J].

Ferrara, N ;

Hillan, KJ ;

Gerber, HP ;

Novotny, W .

NATURE REVIEWS DRUG DISCOVERY, 2004, 3 (05) :391-400

[6] Making a tumour's bed: glioblastoma stem cells and the vascular niche [J].

Gilbertson, Richard J. ;

Rich, Jeremy N. .

NATURE REVIEWS CANCER, 2007, 7 (10) :733-736

[7] Gene Expression Profile Identifies Tyrosine Kinase c-Met as a Targetable Mediator of Antiangiogenic Therapy Resistance [J].

Jahangiri, Arman ;

De Lay, Michael ;

Miller, Liane M. ;

Carbonell, W. Shawn ;

Hu, Yu-Long ;

Lu, Kan ;

Tom, Maxwell W. ;

Paquette, Jesse ;

Tokuyasu, Taku A. ;

Tsao, Sean ;

Marshall, Roxanne ;

Perry, Arie ;

Bjorgan, Kirsten M. ;

Chaumeil, Myriam M. ;

Ronen, Sabrina M. ;

Bergers, Gabriele ;

Aghi, Manish K. .

CLINICAL CANCER RESEARCH, 2013, 19 (07) :1773-1783

[8] Angiogenesis in brain tumours [J].

Jain, Rakesh K. ;

Di Tomaso, Emmanuelle ;

Duda, Dan G. ;

Loeffler, Jay S. ;

Sorensen, A. Gregory ;

Batchelor, Tracy T. .

NATURE REVIEWS NEUROSCIENCE, 2007, 8 (08) :610-622

[9] VEGF Inhibits Tumor Cell Invasion and Mesenchymal Transition through a MET/VEGFR2 Complex [J].

Lu, Kan V. ;

Chang, Jeffrey P. ;

Parachoniak, Christine A. ;

Pandika, Melissa M. ;

Aghi, Manish K. ;

Meyronet, David ;

Isachenko, Nadezda ;

Fouse, Shaun D. ;

Phillips, Joanna J. ;

Cheresh, David A. ;

Park, Morag ;

Bergers, Gabriele .

CANCER CELL, 2012, 22 (01) :21-35

[10] Anti-VEGF/VEGFR Therapy for Cancer: Reassessing the Target [J].

Sitohy, Basel ;

Nagy, Janice A. ;

Dvorak, Harold F. .

CANCER RESEARCH, 2012, 72 (08) :1909-1914

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