pH-responsive chitosan/alginate polyelectrolyte complex membranes reinforced by tripolyphosphate

被引：121
作者：
Gierszewska, Magdalena [1 ]
Ostrowska-Czubenko, Jadwiga [1 ]
Chrzanowska, Ewelina [1 ]
机构：
[1] Nicolaus Copernicus Univ Torun, Fac Chem, Gagarina St 7, PL-87100 Torun, Poland
来源：
EUROPEAN POLYMER JOURNAL | 2018年 / 101卷
关键词：
pH-responsive membranes; Polyelectrolyte complex; Chitosan; Alginate; Tripolyphosphate; Swelling; SODIUM ALGINATE; SWELLING DYNAMICS; CHITOSAN HYDROGELS; CROSS-LINKING; DELIVERY; COPOLYMERS; KINETICS;
D O I：
10.1016/j.eurpolymj.2018.02.031
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
pH-sensitive chitosan/alginate/tripolyphosphate (Ch/Alg/TPP) hydrogel membranes based on chitosan/alginate (Ch/Alg) polyelectrolyte complex and crosslinking agent tripolyphosphate (TPP) were synthesized. An effect of TPP-crosslinking on the molecular structure, crystallinity, morphology, swelling and model drug release behavior of the Ch/Alg membrane was analyzed. The dynamic swelling behavior of the Ch/Alg and Ch/Alg/TPP membranes were studied in solutions of different pH (1.0-9.0). At pH 7.4 or higher Ch/Alg and Ch/Alg/TPP hydrogels showed an untypical swelling behavior, i.e. "overshooting effect". The results showed, that addition of TPP reinforced chitosan/alginate network. The swelling/deswelling behavior of the membranes was investigated at pH = 1.5 (or 3.5) and 9 to confirm the response rate and reversibility of the swelling process. Ch/Alg/TPP membranes exhibited sharp swelling/deswelling behavior and high stability in acidic and basic solutions what makes them suitable candidate for drug delivery systems. Drug release of ascorbic acid from Ch/Alg/TPP membrane was measured in buffer solutions of pH = 3.5 and 7.4.
引用
收藏
页码：282 / 290
页数：9
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