Synthesis and characterization of daunorubicin modified ZnO/PVP nanorods and its photodynamic action

被引：25

作者：

Hariharan, R. ^{[1
]}

Senthilkumar, S. ^{[1
]}

Suganthi, A. ^{[2
]}

Rajarajan, M. ^{[1
]}

机构：

[1] Cardamom Planters Assoc Coll, PG Dept Chem, Bodinayakanur 625513, Tamil Nadu, India

[2] Thiagarajar Coll, PG & Res Dept Chem, Madurai 625009, Tamil Nadu, India

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY | 2013年 / 252卷

关键词：

ZnO nano; Surface modification; Daunorubicin; Singlet oxygen; Photoinactivation; SINGLET OXYGEN; ZNO NANOPARTICLES; IN-VITRO; CANCER-CELLS; NANOMATERIALS; SURFACTANT; DEPENDENCE; MORPHOLOGY; TOXICITY; RADICALS;

D O I：

10.1016/j.jphotochem.2012.11.017

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Nanomaterials have widely been used in the field of biological and biomedicine, such as tissue imaging, diagnosis and cancer therapy. The aim of this study is to investigate cytotoxicity and photodynamic effect of combined application of polyvinyl pyrrolidone (PVP) modified ZnO nanorods with anticancer drug daunorubicin (DNR) in photodynamic therapy (PDT). Daunorubicin (DNR) has a broad spectrum of anticancer activity, but it is limited in clinical application due to its serious side effects. In DNR-ZnO/PVP nanocomposites, ZnO/PVP nanorods act as drug carrier of DNR in drug delivery system (DNR-ZnO/PVP nanocomposites). This drug delivery system induced remarkable improvement in anticancer activity, as demonstrated by MTT assay using 3-(4,5-dimethylthiazol-2yl)-2,5 diphenyl tetrazolium bromide (MTT reagent). This has been also demonstrated by antibacterial activity and DNA cleavage study. The findings suggest that DNR delivery strategy is a promising approach to cancer therapy. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：107 / 115

页数：9

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