Utility of circulating tumor DNA for predicting prognosis in the management of resectable pancreatic cancer

被引：0

作者：

Tyerman, Zachary ^{[1
]}

Ambler, Emily ^{[2
]}

Schlick, Cary Jo R. ^{[1
]}

Nwajei, Felix ^{[4
]}

Chawla, Akhil ^{[1
,2
,3
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Surg, Chicago, IL 60611 USA

[2] Northwestern Univ, Div Surg Oncol, Dept Surg, Northwestern Med Reg Med Grp,Feinberg Sch Med, Chicago, IL 60190 USA

[3] Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA

[4] Duke Univ, Sch Med, Dept Neurol, Durham, NC 27710 USA

来源：

JOURNAL OF CANCER METASTASIS AND TREATMENT | 2022年 / 8卷

关键词：

Pancreatic cancer; circulating tumor DNA; prognosis; survival; DUCTAL ADENOCARCINOMA; DIAGNOSIS; MARKER; RESISTANCE; MUTATIONS; CA19-9; PLASMA; BLOOD; SERUM;

D O I：

10.20517/2394-4722.2022.20

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The measurement of circulating tumor DNA (ctDNA) has been studied in several malignancies, including metastatic pancreatic cancer, but less is known about its utility in monitoring treatment response and recurrence in resectable pancreatic cancer. Methods: We conducted a systematic review of the literature examining the association of ctDNA with overall survival (OS) and disease-free survival. Results: Five articles met our exclusion criteria. Baseline and/or postoperative ctDNA was found to be associated with decreased OS and recurrence-free survival. Discussion: ctDNA has the potential to be used as a prognostic biomarker and to guide therapy in resectable pancreatic cancer.

引用

页数：9

共 38 条

[1]

American Cancer Society, CANC FACTS FIGURES 2

[2] The clinical utility of serum CA 19-9 in the diagnosis, prognosis and management of pancreatic adenocarcinoma: An evidence based appraisal [J].

Ballehaninna, Umashankar K. ;

Chamberlain, Ronald S. .

JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2012, 3 (02) :105-119

[3] Serum CA 19-9 as a Biomarker for Pancreatic Cancer-A Comprehensive Review [J].

Ballehaninna U.K. ;

Chamberlain R.S. .

Indian Journal of Surgical Oncology, 2011, 2 (2) :88-100

[4] Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies [J].

Bettegowda, Chetan ;

Sausen, Mark ;

Leary, Rebecca J. ;

Kinde, Isaac ;

Wang, Yuxuan ;

Agrawal, Nishant ;

Bartlett, Bjarne R. ;

Wang, Hao ;

Luber, Brandon ;

Alani, Rhoda M. ;

Antonarakis, Emmanuel S. ;

Azad, Nilofer S. ;

Bardelli, Alberto ;

Brem, Henry ;

Cameron, John L. ;

Lee, Clarence C. ;

Fecher, Leslie A. ;

Gallia, Gary L. ;

Gibbs, Peter ;

Le, Dung ;

Giuntoli, Robert L. ;

Goggins, Michael ;

Hogarty, Michael D. ;

Holdhoff, Matthias ;

Hong, Seung-Mo ;

Jiao, Yuchen ;

Juhl, Hartmut H. ;

Kim, Jenny J. ;

Siravegna, Giulia ;

Laheru, Daniel A. ;

Lauricella, Calogero ;

Lim, Michael ;

Lipson, Evan J. ;

Marie, Suely Kazue Nagahashi ;

Netto, George J. ;

Oliner, Kelly S. ;

Olivi, Alessandro ;

Olsson, Louise ;

Riggins, Gregory J. ;

Sartore-Bianchi, Andrea ;

Schmidt, Kerstin ;

Shih, Ie-Ming ;

Oba-Shinjo, Sueli Mieko ;

Siena, Salvatore ;

Theodorescu, Dan ;

Tie, Jeanne ;

Harkins, Timothy T. ;

Veronese, Silvio ;

Wang, Tian-Li ;

Weingart, Jon D. .

SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (224)

[5]

Centers for Disease Control and Prevention, 2021, An Update on Cancer Deaths in the United States

[6] Follow-Up Study of K-ras Mutations in the Plasma of Patients With Pancreatic Cancer Correlation With Clinical Features and Carbohydrate Antigen 19-9 [J].

Daebritz, Jan ;

Preston, Roman ;

Haenfler, Joachim ;

Oettle, Helmut .

PANCREAS, 2009, 38 (05) :534-541

[7] Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer [J].

Dawson, Sarah-Jane ;

Tsui, Dana W. Y. ;

Murtaza, Muhammed ;

Biggs, Heather ;

Rueda, Oscar M. ;

Chin, Suet-Feung ;

Dunning, Mark J. ;

Gale, Davina ;

Forshew, Tim ;

Mahler-Araujo, Betania ;

Rajan, Sabrina ;

Humphray, Sean ;

Becq, Jennifer ;

Halsall, David ;

Wallis, Matthew ;

Bentley, David ;

Caldas, Carlos ;

Rosenfeld, Nitzan .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (13) :1199-1209

[8] The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers [J].

Diaz, Luis A., Jr. ;

Williams, Richard T. ;

Wu, Jian ;

Kinde, Isaac ;

Hecht, J. Randolph ;

Berlin, Jordan ;

Allen, Benjamin ;

Bozic, Ivana ;

Reiter, Johannes G. ;

Nowak, Martin A. ;

Kinzler, Kenneth W. ;

Oliner, Kelly S. ;

Vogelstein, Bert .

NATURE, 2012, 486 (7404) :537-540

[9] Circulating mutant DNA to assess tumor dynamics [J].

Diehl, Frank ;

Schmidt, Kerstin ;

Choti, Michael A. ;

Romans, Katharine ;

Goodman, Steven ;

Li, Meng ;

Thornton, Katherine ;

Agrawal, Nishant ;

Sokoll, Lori ;

Szabo, Steve A. ;

Kinzler, Kenneth W. ;

Vogelstein, Bert ;

Diaz, Luis A., Jr. .

NATURE MEDICINE, 2008, 14 (09) :985-990

[10] Tumor markers in pancreatic cancer: a European Group on Tumor Markers (EGTM) status report [J].

Duffy, M. J. ;

Sturgeon, C. ;

Lamerz, R. ;

Haglund, C. ;

Holubec, V. L. ;

Klapdor, R. ;

Nicolini, A. ;

Topolcan, O. ;

Heinemann, V. .

ANNALS OF ONCOLOGY, 2010, 21 (03) :441-447

← 1 2 3 4 →