Utility of circulating tumor DNA for predicting prognosis in the management of resectable pancreatic cancer

被引：0
作者：
Tyerman, Zachary [1 ]
Ambler, Emily [2 ]
Schlick, Cary Jo R. [1 ]
Nwajei, Felix [4 ]
Chawla, Akhil [1 ,2 ,3 ]
机构：
[1] Northwestern Univ, Feinberg Sch Med, Dept Surg, Chicago, IL 60611 USA
[2] Northwestern Univ, Div Surg Oncol, Dept Surg, Northwestern Med Reg Med Grp,Feinberg Sch Med, Chicago, IL 60190 USA
[3] Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA
[4] Duke Univ, Sch Med, Dept Neurol, Durham, NC 27710 USA
来源：
JOURNAL OF CANCER METASTASIS AND TREATMENT | 2022年 / 8卷
关键词：
Pancreatic cancer; circulating tumor DNA; prognosis; survival; DUCTAL ADENOCARCINOMA; DIAGNOSIS; MARKER; RESISTANCE; MUTATIONS; CA19-9; PLASMA; BLOOD; SERUM;
D O I：
10.20517/2394-4722.2022.20
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: The measurement of circulating tumor DNA (ctDNA) has been studied in several malignancies, including metastatic pancreatic cancer, but less is known about its utility in monitoring treatment response and recurrence in resectable pancreatic cancer. Methods: We conducted a systematic review of the literature examining the association of ctDNA with overall survival (OS) and disease-free survival. Results: Five articles met our exclusion criteria. Baseline and/or postoperative ctDNA was found to be associated with decreased OS and recurrence-free survival. Discussion: ctDNA has the potential to be used as a prognostic biomarker and to guide therapy in resectable pancreatic cancer.
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页数：9
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