STRUCTURAL BIOLOGY A toolbox for protein design

被引:6
作者
Hoecker, Birte [1 ]
机构
[1] Max Planck Inst Dev Biol, D-72076 Tubingen, Germany
关键词
COMPUTATIONAL ENZYME DESIGN; FOLD;
D O I
10.1038/491204a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Some of the principles underlying how amino-acid sequences determine the three-dimensional structures of proteins have been defined. This has enabled a successful approach to designing protein folds from scratch. See Article p.222
引用
收藏
页码:204 / 205
页数:2
相关论文
共 9 条
[1]   An exciting but challenging road ahead for computational enzyme design [J].
Baker, David .
PROTEIN SCIENCE, 2010, 19 (10) :1817-1819
[2]   Principles for designing ideal protein structures [J].
Koga, Nobuyasu ;
Tatsumi-Koga, Rie ;
Liu, Gaohua ;
Xiao, Rong ;
Acton, Thomas B. ;
Montelione, Gaetano T. ;
Baker, David .
NATURE, 2012, 491 (7423) :222-227
[3]   Design of a switchable eliminase [J].
Korendovych, Ivan V. ;
Kulp, Daniel W. ;
Wu, Yibing ;
Cheng, Hong ;
Roder, Heinrich ;
DeGrado, William F. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (17) :6823-6827
[4]   Design of a novel globular protein fold with atomic-level accuracy [J].
Kuhlman, B ;
Dantas, G ;
Ireton, GC ;
Varani, G ;
Stoddard, BL ;
Baker, D .
SCIENCE, 2003, 302 (5649) :1364-1368
[5]   PROTEIN FOLDING FUNNELS - A KINETIC APPROACH TO THE SEQUENCE STRUCTURE RELATIONSHIP [J].
LEOPOLD, PE ;
MONTAL, M ;
ONUCHIC, JN .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (18) :8721-8725
[6]   STEREOCHEMISTRY OF POLYPEPTIDE CHAIN CONFIGURATIONS [J].
RAMACHANDRAN, GN ;
RAMAKRISHNAN, C ;
SASISEKHARAN, V .
JOURNAL OF MOLECULAR BIOLOGY, 1963, 7 (01) :95-&
[7]   Kemp elimination catalysts by computational enzyme design [J].
Rothlisberger, Daniela ;
Khersonsky, Olga ;
Wollacott, Andrew M. ;
Jiang, Lin ;
DeChancie, Jason ;
Betker, Jamie ;
Gallaher, Jasmine L. ;
Althoff, Eric A. ;
Zanghellini, Alexandre ;
Dym, Orly ;
Albeck, Shira ;
Houk, Kendall N. ;
Tawfik, Dan S. ;
Baker, David .
NATURE, 2008, 453 (7192) :190-U4
[8]   Computational design of ligand binding is not a solved problem [J].
Schreier, Bettina ;
Stumpp, Christian ;
Wiesner, Silke ;
Hoecker, Birte .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (44) :18491-18496
[9]   Versatility, stability, and evolution of the (βα)8-barrel enzyme fold [J].
Sterner, R ;
Höcker, B .
CHEMICAL REVIEWS, 2005, 105 (11) :4038-4055