Inflammation and diminished iron status: mechanisms and functional outcomes

被引：28
作者：
Gaffney-Stomberg, Erin [1 ]
McClung, James P. [1 ]
机构：
[1] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA
来源：
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE | 2012年 / 15卷 / 06期
关键词：
cognition; hepcidin; inflammation; iron; obesity; physical performance; REGULATORY HORMONE HEPCIDIN; PLACEBO-CONTROLLED TRIAL; FEMALE SOLDIERS; ENDURANCE CAPACITY; SERUM HEPCIDIN; ACUTE EXERCISE; DOUBLE-BLIND; WOMEN; HEMOJUVELIN; EXPRESSION;
D O I：
10.1097/MCO.0b013e328357f63b
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Purpose of review To summarize recent findings regarding the effects of inflammation on iron (Fe) metabolism and to review studies detailing the influence of poor Fe status on physical and cognitive performance. Recent findings Hepatic expression and release of hepcidin, a negative regulator of Fe status, is increased by the actions of the inflammatory cytokine interleukin-6. Inflammation associated with chronic disease, obesity, and exercise is associated with elevated interleukin-6 and hepcidin levels, which may result in diminished Fe status. Summary Decrements in Fe status due to insufficient dietary Fe intake and/or the inflammatory response may degrade physical and cognitive performance. Future studies should clarify whether dietary or other therapeutic interventions to mitigate inflammation attenuate hepcidin-mediated declines in Fe status.
引用
收藏
页码：605 / 613
页数：9
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