Differential regulation of the expression of nucleotide pyrophosphatases phosphodiesterases in rat liver

被引:41
|
作者
Stefan, C [1 ]
Gijsbers, R [1 ]
Stalmans, W [1 ]
Bollen, M [1 ]
机构
[1] Katholieke Univ Leuven, Fac Geneeskunde, Afdeling Biochem, B-3000 Louvain, Belgium
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 1999年 / 1450卷 / 01期
关键词
nucleotide pyrophosphatase; phosphodiesterase I; PC-1; autotaxin; B10;
D O I
10.1016/S0167-4889(99)00031-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We propose the name nucleotide pyrophosphatases/phosphodiesterases (NPP) for the enzymes that release nucleoside-5'-monophosphates from various pyrophosphate and phosphodiester bonds. Three structurally related mammalian NPPs are known, i.e. NPP alpha (autotaxin), NPP beta (B10/gp130(RB13-6)) and NPP gamma (PC-1). We report here that these isozymes have a distinct tissue distribution in the rat but that they are all three expressed in hepatocytes. In FAO rat hepatoma cells only the level of NPP gamma was stimulated by TGF-beta(1). In rat liver, the concentration of the transcripts of all three isozymes was found to increase manyfold during the first weeks after birth, but the increased expression of the NPP alpha mRNA was transient. The level of the NPP transcripts transiently decreased after hepatectomy, but NPP alpha mRNA was also lost after sham operation, which suggests that it may belong to the negative acute-phase proteins. The loss of the beta- and gamma-transcripts after hepatectomy was not due to a decreased NPP gene transcription or an increased turnover of the mature transcripts. However, hepatectomy also caused a similar loss of the nuclear pool of the NPP beta and NPP gamma mRNAs. We conclude that a deficient processing and/or an increased turnover of the NPP pre-mRNAs underlies the hepatectomy-induced decrease of the beta- and gamma-transcripts. A similar loss of nuclear NPP gamma mRNA was also noted after treatment with cycloheximide, indicating that protein(s) with a high turnover control the stability and/or processing of the immature NPP gamma transcript. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:45 / 52
页数:8
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