MHC Class I related chain A (MICA), Human Leukocyte Antigen (HLA)-DRB1, HLA-DQB1 genotypes in Turkish patients with ulcerative colitis

被引：0

作者：

Cinar, Cigdem Kekik ^{[1
]}

Demir, Kadir ^{[2
]}

Temurhan, Sonay ^{[1
]}

Akyuz, Filiz ^{[2
]}

Pinarbasi, Binnur ^{[2
]}

Oguz, Fatma Savran ^{[3
]}

机构：

[1] Istanbul Univ, Med Biol, Istanbul Fac Med, Istanbul, Turkey

[2] Istanbul Univ, Istanbul Fac Med, Internal Med, Gastroenterohepatol, Istanbul, Turkey

[3] Istanbul Univ, Med Biol, Istanbul, Turkey

来源：

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI | 2020年 / 45卷 / 05期

关键词：

HLA-DQB1; HLA-DRB1; MICA; ulcerative colitis; INFLAMMATORY-BOWEL-DISEASE; GENE-A MICA; T-CELLS; HLA-DRB1; ALLELES; CROHNS-DISEASE; POLYMORPHISM; ASSOCIATION; SUSCEPTIBILITY; NKG2D; EXPRESSION;

D O I：

10.1515/tjb-2019-0296

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Objectives: We aimed to determine Human Leukocyte Antigen (HLA)-DRB1, DQB1, and MHC Class I related chain A (MICA) genotypes in patients with ulcerative colitis. Methods: HLA-DRB1, HLA-DQB1, MICA genotyping of patient (n:85) and controls (n:100) were performed by PCR-SSO Luminex (One Lambda genotyping kit). Results: We found significantly higher DRB1*01 (p:0.022, OR:0.23, CI:0.06-0.8) and MICA*0002/20/55 (p:0.03, OR:0.53, CI:0.29-0.93) alleles in control group whereas DRB1*14 (p:0.04, OR:2.25, CI:1-5.08), DRB1*15 (p:<0.0001, OR:4.54, CI:2.09-9.88) and MICA*0004 (p:0.01, OR:2.84, CI:1.2-6.7) alleles were higher in patient group. Conclusions: The present study will inform the MICA and HLA genotypes about the protective (DRB1*01, MICA*0002/20/55) or susceptible (DRB1*14, DRB1*15, MICA*0004) alleles of the disease and helps the literature on Turkish patients with ulcerative colitis.

引用

页码：587 / 592

页数：6

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