Novel mechanism of macrolide resistance in Streptococcus pneumoniae

被引：95

作者：

Shortridge, VD ^{[1
]}

Flamm, RK ^{[1
]}

Ramer, N ^{[1
]}

Beyer, J ^{[1
]}

Tanaka, SK ^{[1
]}

机构：

[1] ABBOTT LABS,ABBOTT PK,IL 60064

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 1996年 / 26卷 / 02期

关键词：

D O I：

10.1016/S0732-8893(96)00183-6

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The mechanism of macrolide resistance was examined in 73 clinical isolates of Streptococcus pneumoniae. Two distinct resistance phenotypes were observed: high-level macrolides-lincosamides-streptogramin B (MLS) resistance and low-level macrolide resistance with lincosamide susceptibility. High-level MLS resistance was associated with the presence of ermAM. Strains with the low-level resistant phenotype (novel) were negative for ermA, ermC, ermAM, ereA, ereB and msrA by polymerase chain reaction (PCR) amplification with gene-specific primers. Ribosomes isolated from novel strains bound the same amount of [C-14]-erythromycin as ribosomes from sensitive strains. These novel strains also did not inactivate the macrolide. The novel mechanism was found in 41% of the erythromycin resistant S. pneumoniae examined. (C) 1996 Elsevier Science Inc.

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页码：73 / 78

页数：6

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