In vitro anti-inflammatory activity of lignans isolated from Magnolia fargesii

被引：73

作者：

Kim, Jae Yeon ^{[1
]}

Lim, Hyo Jin ^{[1
]}

Lee, Da Yeon ^{[1
]}

Kim, Ji Sun ^{[1
]}

Kim, Do Hee ^{[1
]}

Lee, Hwa Jin ^{[1
]}

Kim, Hee Doo ^{[1
]}

Jeon, Raok ^{[1
]}

Ryu, Jae-Ha ^{[1
]}

机构：

[1] Sookmyung Womens Univ, Coll Pharm, Seoul 140742, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 03期

关键词：

Magnolia fargesii; Nitric oxide; Prostaglandin E-2; Microglia; NITRIC-OXIDE SYNTHASES; FLOWER BUDS; SELECTIVE INHIBITOR; FLOS-MAGNOLIAE; LIPOPOLYSACCHARIDE; STEREOCHEMISTRY; EXPRESSION; CYCLOOXYGENASE-2; DERIVATIVES; ASSIGNMENT;

D O I：

10.1016/j.bmcl.2008.11.103

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The overproduction of nitric oxide (NO) and prostaglandin E-2 (PGE(2)) causes neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Four lignans, (+)-eudesmin (1), (+)-magnolin (2), (+)yangambin (3) and a new structure named as epimagnolin B (4) were isolated from Magnolia fargesii (Magnoliaceae) as the inhibitors of NO production in LPS-activated microglia. The most potent compound 4 inhibited the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the suppression of I-kappa B-alpha degradation and nuclear translocation of p65 subunit of NF-kappa B. (C) 2009 Published by Elsevier Ltd.

引用

页码：937 / 940

页数：4

共 35 条

[1] Expression of inducible nitric oxide synthase and cyclooxygenase-2 after excitotoxic damage to the immature rat brain [J].

Acarin, L ;

Peluffo, H ;

González, B ;

Castellano, B .

JOURNAL OF NEUROSCIENCE RESEARCH, 2002, 68 (06) :745-754

[2] Two highly oxygenated eudesmanes and 10 lignans from Achillea holosericea [J].

Ahmed, AA ;

Mahmoud, AA ;

Ali, ET ;

Tzakou, O ;

Couladis, M ;

Mabry, TJ ;

Gáti, T ;

Tóth, G .

PHYTOCHEMISTRY, 2002, 59 (08) :851-856

[3] Inhibitory activity of lignan components from the flower buds of Magnoliae fargesii on the expression of cell adhesion molecules [J].

Ahn, KS ;

Jung, KY ;

Kim, JH ;

Oh, SR ;

Lee, HK .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2001, 24 (09) :1085-1087

[4] Nitric oxide synthases: structure, function and inhibition [J].

Alderton, WK ;

Cooper, CE ;

Knowles, RG .

BIOCHEMICAL JOURNAL, 2001, 357 (03) :593-615

[5] Nitric oxide synthases:: targets for therapeutic strategies in neurological diseases [J].

Chabrier, PE ;

Demerlé-Pallardy, C ;

Auguet, M .

CELLULAR AND MOLECULAR LIFE SCIENCES, 1999, 55 (8-9) :1029-1035

[6] STUDIES ON THE CA++-ANTAGONISTIC SUBSTANCES IN CHINESE HERBS .2. ON THE CA++-ANTAGONISTIC PRINCIPLES OF THE FLOWER BUDS OF MAGNOLIA-FARGESII [J].

CHEN, CC ;

HUANG, YL ;

CHEN, HT ;

CHEN, YP ;

HSU, HY .

PLANTA MEDICA, 1988, (05) :438-440

[7]

Choi SH, 2003, J NEUROSCI, V23, P5877

[8] NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease [J].

Colton, C. A. ;

Vitek, M. P. ;

Wink, D. A. ;

Xu, Q. ;

Cantillana, V. ;

Previti, M. L. ;

Van Nostrand, W. E. ;

Weinberg, B. ;

Dawson, H. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (34) :12867-12872

[9] Beneficial effects of GW274150, a novel, potent and selective inhibitor of NOS activity, in a rodent model of collagen-induced arthritis [J].

Cuzzocrea, S ;

Chatterjee, PK ;

Mazzon, E ;

McDonald, MC ;

Dugo, L ;

Di Paola, R ;

Serraino, I ;

Britti, D ;

Caputi, AP ;

Thiemermann, C .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2002, 453 (01) :119-129

[10] ANALYSIS OF NITRATE, NITRITE, AND [N-15]-LABELED NITRATE IN BIOLOGICAL-FLUIDS [J].

GREEN, LC ;

WAGNER, DA ;

GLOGOWSKI, J ;

SKIPPER, PL ;

WISHNOK, JS ;

TANNENBAUM, SR .

ANALYTICAL BIOCHEMISTRY, 1982, 126 (01) :131-138

← 1 2 3 4 →