Pain management during and after thoracotomy is challenging in premature neonates. Ultrasound-guided fascial plane block techniques, such as the erector spinae plane block are a relatively new regional anesthesia technique and have emerged as an alternative to thoracic epidural due to its clinical effectiveness, ease of administration and theoretically being safer to perform. The relative ease of identifying anatomical landmarks compared to theparavertebral block, as well as its safety profile compared to an epidural, may have contributedto the erector spinae plane Bs growing popularity. Currently, however, the published evidencefor the efficacy of regional anesthesia techniques in low birth weight newborns undergoing thissurgery is limited to few isolated case reports. Herein we describe the use of unilateral erectorspinae plane block as part of anesthesia and postoperative analgesia management of surgicalcorrection of esophageal atresia in a preterm neonate. (c) 2021 Sociedad Espa similar to nola de Anestesiolog ' ia, Reanimaci ' on y Terap ' eutica del Dolor. Publishedby Elsevier Espa similar to na, S.L.U. All rights reserved.