Stimuli-responsive Unimer Nanoparticles Composed of Poly(amino acid) Derivatives as Promising Protein-mimetic Drug Carriers

被引：4
|
作者：
Piyapakorn, Phassamon [1 ]
Akagi, Takami [1 ]
Akashi, Mitsuru [1 ]
机构：
[1] Osaka Univ, Grad Sch Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan
来源：
CHEMISTRY LETTERS | 2013年 / 42卷 / 12期
基金：
日本学术振兴会;
关键词：
POLYMERIC MICELLES; BLOCK-COPOLYMER;
D O I：
10.1246/cl.130830
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Stimuli-responsive unimer nanoparticles (NPs) composed of hydrophobized poly(gamma-glutamic acid) were successfully prepared by a combination of hydrophobic interactions and disulfide bonds. The formation of hydrophobic associations and the existence of disulfide bonds were confirmed by UV spectroscopy and by treatment with dithiothreitol, respectively. Moreover, the release of hydrophobic drugs in response to a reducing agent was observed when compared to nonstimulus unimer NPs. These 10 nm-sized unimer NPs will be useful as reduction-responsive carriers.
引用
收藏
页码：1534 / 1536
页数：3
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