A one-pot synthesis of isoindolin-1-imine derivatives

被引：6
|
作者：
Khangvan Pham [1 ]
Zhang, Zhongguo [1 ]
Shen, Sida [1 ]
Ma, Lei [1 ]
Hu, Lihong [1 ,2 ]
机构：
[1] E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China
来源：
TETRAHEDRON | 2013年 / 69卷 / 51期
基金：
中国国家自然科学基金;
关键词：
2-Cyanobenzaldehyde; 4-Hydroxycoumarin; Isoindolin-l-imine; 4-Hydroxyquinolin-2(1H)-one; One-pot reaction; THIAMINE HYDROCHLORIDE; GLYCINE SITE; RECEPTOR; ANTAGONISTS; DICUMAROL; BINDING; AMINO;
D O I：
10.1016/j.tet.2013.10.076
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-pot procedure was developed for the synthesis of isoindolin-l-imine derivatives by a simple three-component condensation of 2-cyanobenzaldhyde, ammonium acetate, and 4-hyroxycoumarin derivatives or 1,3-dicarbonyl compounds or 4-hydroxyquinolin-2(1H)-one in ethanol under reflux for 20-60 min with excellent yields. The advantages of this procedure are operational simplicity, excellent yields, and short reactive time, without catalyst, easy workup, and green environmental impact. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：10933 / 10939
页数：7
相关论文
共 50 条
  • [21] One-pot and efficient protocol for synthesis of quinoxaline derivatives
    Islami, Mohammad Reza
    Hassani, Zahra
    ARKIVOC, 2008, : 280 - 287
  • [22] A facile one-pot Friedlander synthesis of quinoline derivatives
    Reddy, P. Prabhakar
    Raju, B. China
    Rao, J. Madhusudana
    JOURNAL OF CHEMICAL RESEARCH, 2008, (12) : 679 - 682
  • [23] One-pot synthesis of azanucleosides from proline derivatives
    Boto, Alicia
    Hernandez, Dacil
    Hernandez, Rosendo
    TETRAHEDRON LETTERS, 2008, 49 (03) : 455 - 458
  • [24] One-pot synthesis of benzochromeno-pyrazole derivatives
    Heravi, Majid M.
    Saeedi, Mina
    Beheshtiha, Yahya S.
    Oskooie, Hossein A.
    MOLECULAR DIVERSITY, 2011, 15 (01) : 239 - 243
  • [25] Traceless selenocarboxylates for the one-pot synthesis of amides and derivatives
    Silva, Luana
    Rosario, Alisson R.
    Machado, Bianca M.
    Ludtke, Diogo S.
    TETRAHEDRON, 2021, 79
  • [26] One-pot synthesis of benzochromeno-pyrazole derivatives
    Majid M. Heravi
    Mina Saeedi
    Yahya S. Beheshtiha
    Hossein A. Oskooie
    Molecular Diversity, 2011, 15 : 239 - 243
  • [27] One-pot synthesis and chiral analysis of cyclopropane derivatives
    Ghanem, A
    Aboul-Enein, HY
    Müller, P
    CHIRALITY, 2005, 17 (01) : 44 - 50
  • [28] A novel one-pot synthesis of derivatives of aryldioxins and aryldithiins
    Preedasuriyachai, P
    Charoonniyomporn, P
    Karoonnirun, O
    Thongpanchang, T
    Thebtaranonth, Y
    TETRAHEDRON LETTERS, 2004, 45 (07) : 1343 - 1346
  • [29] One-pot photoenzymatic synthesis of β-chiral malononitrile derivatives
    Fan, Xin-Yue
    Yu, Yuan
    Lin, Ru-De
    Yao, Yao
    Shi, Ming-Liang
    Li, Kun
    Yu, Xiao-Qi
    Liu, Yan-Hong
    Wang, Na
    ORGANIC CHEMISTRY FRONTIERS, 2024, 11 (18): : 5179 - 5187
  • [30] One-pot synthesis of isoxazoline derivatives by sonochemical activation
    Bougrin, K
    Lamiri, M
    Soufiaoui, M
    TETRAHEDRON LETTERS, 1998, 39 (25) : 4455 - 4458
12345