High serum YKL-40 level positively correlates with coronary artery disease

被引：2

作者：

Jin, Yan ^{[1
]}

Cao, Jia-Ning ^{[1
]}

Wang, Chun-Xia ^{[1
]}

Feng, Qiu-Ting ^{[1
]}

Ye, Xin-He ^{[1
]}

Xu, Xin ^{[1
]}

Yang, Cheng-Jian ^{[1
]}

机构：

[1] Nanjing Med Univ, WuXi Hosp 2, Dept Cardiol, 68 Zhongshan Rd, Wuxi 214002, Peoples R China

来源：

BIOMARKERS IN MEDICINE | 2017年 / 11卷 / 02期

关键词：

CAD; coronary artery disease; diagnosis; Gensini score; predictive value; ROC curve; sensitivity; serum; specificity; YKL-40; HEART-DISEASE; INFLAMMATORY BIOMARKER; PROMOTER REGION; PLASMA YKL-40; ATHEROSCLEROSIS; CHI3L1; MARKER; GENE; EXPRESSION; PREDICTION;

D O I：

10.2217/bmm-2016-024

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: We investigated the predictive value of chitinase-like protein YKL-40 in coronary artery disease (CAD). Patients: Serum YKL-40 levels in 116 CAD patients and 82 healthy controls were analyzed. Severity of CAD was evaluated using Gensini scores. Spearman's correlation was used to evaluate the correlation between Gensini scores and YKL-40 levels. The predictive value of YKL-40 was determined by receivers operating characteristic curve analysis. Results: Serum YKL-40 levels were significantly elevated in CAD group as compared with control group. A positive correlation was found between the serum YKL-40 level and Gensini score. The optimum cut-off value of YKL-40 concentration was 127.7 ng/ ml for distinguishing CAD patients from healthy controls with a 75.9% sensitivity and 57.3% specificity. Conclusion: A positive correlation exists between YKL-40 levels and CAD, and YKL-40 might be a useful adjunct in the diagnosis of CAD.

引用

页码：133 / 139

页数：7

共 50 条

[21] Increased serum YKL-40 level is associated with the presence and severity of metabolic syndrome [J].

Akboga, Mehmet Kadri ;

Yalcin, Ridvan ;

Sahinarslan, Asife ;

Demirtas, Canan Yilmaz ;

Pasaoglu, Hatice ;

Abaci, Adnan .

ANATOLIAN JOURNAL OF CARDIOLOGY, 2016, 16 (12) :953-958

[22] Serum YKL-40, a prognostic marker in patients with large-artery atherosclerotic stroke [J].

Chen, X. -L. ;

Li, Q. ;

Huang, W. -S. ;

Lin, Y. -S. ;

Xue, J. ;

Wang, B. ;

Jin, K. -L. ;

Shao, B. .

ACTA NEUROLOGICA SCANDINAVICA, 2017, 136 (02) :97-102

[23] Fasting Serum Level of Fatty-Acid-Binding Protein 4 Positively Correlates With Metabolic Syndrome in Patients With Coronary Artery Disease [J].

Hsu, Bang-Gee ;

Chen, Yu-Chih ;

Lee, Ru-Ping ;

Lee, Chia-Chi ;

Lee, Chung-Jen ;

Wang, Ji-Hung .

CIRCULATION JOURNAL, 2010, 74 (02) :327-331

[24] Circulating lncRNA ANRIL level positively correlates with disease risk, severity, inflammation level and poor prognosis of coronary artery disease [J].

Qin, Zheng ;

Liu, Danan .

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2019, 12 (07) :8964-8970

[25] Serum Endocan Level and the Severity of Coronary Artery Disease: A Pilot Study [J].

Kose, Murat ;

Emet, Samim ;

Akpinar, Timur Selcuk ;

Kocaaga, Mehmet ;

Cakmak, Ramazan ;

Akarsu, Murat ;

Yuruyen, Gulden ;

Arman, Yucel ;

Tukek, Tufan .

ANGIOLOGY, 2015, 66 (08) :727-731

[26] YKL-40 Protein Correlates with the Phenotype of Asthma [J].

Specjalski, Krzysztof ;

Chelminska, Marta ;

Jassem, Ewa .

LUNG, 2015, 193 (02) :189-194

[27] Plasma YKL-40 levels correlate with the severity of coronary atherosclerosis assessed with the SYNTAX score [J].

Sciborski, Krzysztof ;

Kuliczkowski, Wiktor ;

Karolko, Bozena ;

Bednarczyk, Dawid ;

Protasiewicz, Marcin ;

Mysiak, Andrzej ;

Negrusz-Kawecka, Marta .

POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ, 2018, 128 (11) :644-648

[28] Association between serum YKL-40 level and dysglycemia in cystic fibrosis [J].

Bouvet, Guillaume F. ;

Maignan, Maxime ;

Arslanian, Elizabeth ;

Coriati, Adele ;

Rabasa-Lhoret, Remi ;

Berthiaume, Yves .

CYTOKINE, 2015, 71 (02) :296-301

[29] Prognostic effect of serum and tissue YKL-40 levels in bladder cancer [J].

Tschirdewahn, Stephan ;

Reis, Henning ;

Niedworok, Christian ;

Nyirady, Peter ;

Szendroei, Attila ;

Schmid, Kurt W. ;

Shariat, Shahrokh F. ;

Kramer, Gero ;

vom Dorp, Frank ;

Ruebben, Herbert ;

Szarvas, Tibor .

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 2014, 32 (05) :663-669

[30] Serum YKL-40 is a marker of prognosis and disease status in high-grade gliomas [J].

Iwamoto, Fabio M. ;

Hottinger, Andreas F. ;

Karimi, Sasan ;

Riedel, Elyn ;

Dantis, Jocelynn ;

Jahdi, Maryam ;

Panageas, Katherine S. ;

Lassman, Andrew B. ;

Abrey, Lauren E. ;

Fleisher, Martin ;

DeAngelis, Lisa M. ;

Holland, Eric C. ;

Hormigo, Adilia .

NEURO-ONCOLOGY, 2011, 13 (11) :1244-1251

← 1 2 3 4 5 →