Fluctuating periodic solutions and moment boundedness of a stochastic model for the bone remodeling process

被引:12
作者
Jerez, S. [1 ]
Diaz-Infante, S. [2 ]
Chen, B. [3 ]
机构
[1] CIMAT, Dept Appl Math, Guanajuato 36240, Gto, Mexico
[2] Univ Sonora, CONACYT, Dept Math, Hermosillo, Sonora, Mexico
[3] Univ Texas Arlington, Arlington, TX 76019 USA
关键词
Bone remodeling; Stochastic differential equations; Brownian motion; Moment boundedness; Fluctuating periodic solution; Osteoclasts; Osteoblasts; DIFFERENTIAL-EQUATIONS; MATHEMATICAL-MODEL; COEFFICIENTS; OSTEOBLAST; STABILITY; SIR;
D O I
10.1016/j.mbs.2018.03.006
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
In this work, we model osteoclast-osteoblast population dynamics with random environmental fluctuations in order to understand the random variations of the bone remodeling process in real life. For this purpose, we construct a stochastic differential model for the interactions between the osteoclast and osteoblast cell populations using the parameter perturbation technique. We prove the existence of a globally attractive positive unique solution for the stochastically perturbed system. Also, the stochastic boundedness of the solution is demonstrated using its p-th order moments for p >= 1. Finally, we show that the introduction of noise in the deterministic model provides a fluctuating periodic solution. Numerical evidence supports our theoretical results and a discussion of the results is carried out.
引用
收藏
页码:153 / 164
页数:12
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