Life time-circadian clocks, mitochondria and metabolism

被引:30
作者
Langmesser, S [1 ]
Albrecht, U [1 ]
机构
[1] Univ Fribourg, Div Biochem, Dept Med, CH-1700 Fribourg, Switzerland
关键词
oxidative phosphorylation; complex I; apoptosis; aging; neurodegenerative diseases; circadian clock; mitochondria; metabolism;
D O I
10.1080/07420520500464437
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
A functional circadian clock has long been considered a selective advantage. Accumulating evidence shows that the clock coordinates a variety of physiological processes in order to schedule them to the optimal time of day and thus to synchronize metabolism to changes in external conditions. In mitochondria, both metabolic and cellular defense mechanisms are carefully regulated. Abnormal clock function, might influence mitochondrial function, resulting in decreased fitness of an organism.
引用
收藏
页码:151 / 157
页数:7
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