Suppression of biofilm related, device-associated infections by staphylococcal quorum sensing inhibitors

被引：41
作者：
Kiran, M. D. [1 ]
Giacometti, A. [2 ]
Cirioni, O. [2 ]
Balaban, N. [1 ]
机构：
[1] Tufts Univ, Cummings Sch Vet Med, Dept Biomed Sci, North Grafton, MA 01536 USA
[2] Univ Ancona, Inst Infect Dis & Publ Hlth, Ancona, Italy
来源：
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS | 2008年 / 31卷 / 09期
关键词：
Biofilm; Quorum sensing; RIP; RAP; TRAP; agr; Staphylococci;
D O I：
10.1177/039139880803100903
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Staphylococcal spp. are notorious for causing biofilm-related device-associated infections, leading to tens of thousands of deaths per year In this paper we review quorum sensing inhibitors as potential therapeutics for even the most persistent infections. The animal models reviewed are subcutaneous graft, central venous catheter (CVC), ureteral stent and wound models, and a wound case study. The therapeutic approaches reviewed are the use of RNAIII inhibiting peptide (RIP) and its non-peptide analog. These have been shown to prevent or treat infections caused by any staphylococcal strain tested, including antibiotic-resistant strains like CA-MRSA USA300. (Int J Artif Organs 2008; 31: 761-70)
引用
收藏
页码：761 / 770
页数：10
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