Suppression of biofilm related, device-associated infections by staphylococcal quorum sensing inhibitors

被引:41
作者
Kiran, M. D. [1 ]
Giacometti, A. [2 ]
Cirioni, O. [2 ]
Balaban, N. [1 ]
机构
[1] Tufts Univ, Cummings Sch Vet Med, Dept Biomed Sci, North Grafton, MA 01536 USA
[2] Univ Ancona, Inst Infect Dis & Publ Hlth, Ancona, Italy
关键词
Biofilm; Quorum sensing; RIP; RAP; TRAP; agr; Staphylococci;
D O I
10.1177/039139880803100903
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Staphylococcal spp. are notorious for causing biofilm-related device-associated infections, leading to tens of thousands of deaths per year In this paper we review quorum sensing inhibitors as potential therapeutics for even the most persistent infections. The animal models reviewed are subcutaneous graft, central venous catheter (CVC), ureteral stent and wound models, and a wound case study. The therapeutic approaches reviewed are the use of RNAIII inhibiting peptide (RIP) and its non-peptide analog. These have been shown to prevent or treat infections caused by any staphylococcal strain tested, including antibiotic-resistant strains like CA-MRSA USA300. (Int J Artif Organs 2008; 31: 761-70)
引用
收藏
页码:761 / 770
页数:10
相关论文
共 57 条
  • [1] Controlling biofilms of gram-positive pathogenic bacteria
    Abraham, Wolf-Rainer
    [J]. CURRENT MEDICINAL CHEMISTRY, 2006, 13 (13) : 1509 - 1524
  • [2] RNAIII-inhibiting-peptide-loaded in vivo Polymethylmethacrylate prevents in vivo Staphylococcus aureus biofilm formation
    Anguita-Alonso, Paloma
    Giacometti, Andrea
    Cirioni, Oscar
    Ghiselli, Roberto
    Orlando, Fiorenza
    Saba, Vittorio
    Scalise, Giorgio
    Sevo, Milica
    Tuzova, Marina
    Patel, Robin
    Balaban, Naomi
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (07) : 2594 - 2596
  • [3] Serial surveillance cultures of skin and catheter hub specimens from critically ill patients with central venous catheters: Molecular epidemiology of infection and implications for clinical management and research
    Atela, I
    Coll, P
    Rello, J
    Quintana, E
    Barrio, J
    March, F
    Sanchez, F
    Barraquer, P
    Ballus, J
    Cotura, A
    Prats, G
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1997, 35 (07) : 1784 - 1790
  • [4] Prevention of diseases caused by Staphylococcus aureus using the peptide RIP
    Balaban, N
    Collins, LV
    Cullor, JS
    Hume, EB
    Medina-Acosta, E
    da Motta, OV
    O'Callaghan, R
    Rossitto, PV
    Shirtliff, ME
    da Silveira, LS
    Tarkowski, A
    Torres, JV
    [J]. PEPTIDES, 2000, 21 (09) : 1301 - 1311
  • [5] Prevention of Staphylococcal biofilm-associated infections by the quorum sensing inhibitor RIP
    Balaban, N
    Stoodley, P
    Fux, CA
    Wilson, S
    Costerton, JW
    Dell'Acqua, G
    [J]. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2005, (437) : 48 - 54
  • [6] A chimeric peptide composed of a dermaseptin derivative and an RNA III-inhibiting peptide prevents graft-associated infections by antibiotic-resistant staphylococci
    Balaban, N
    Gov, Y
    Giacometti, A
    Cirioni, O
    Ghiselli, R
    Mocchegiani, F
    Orlando, F
    D'Amato, G
    Saba, V
    Scalise, G
    Bernes, S
    Mor, A
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (07) : 2544 - 2550
  • [7] Use of the quorum-sensing inhibitor RNAIII-inhibiting peptide to prevent biofilm formation in vivo by drug-resistant Staphylococcus epidermidis
    Balaban, N
    Giacometti, A
    Cirioni, O
    Gov, Y
    Ghiselli, R
    Mocchegiani, F
    Viticchi, C
    Del Prete, MS
    Saba, V
    Scalise, G
    Dell'Acqua, G
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2003, 187 (04) : 625 - 630
  • [8] AUTOCRINE REGULATION OF TOXIN SYNTHESIS BY STAPHYLOCOCCUS-AUREUS
    BALABAN, N
    NOVICK, RP
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (05) : 1619 - 1623
  • [9] Autoinducer of virulence as a target for vaccine and therapy against Staphylococcus aureus
    Balaban, N
    Goldkorn, T
    Nhan, RT
    Dang, LB
    Scott, S
    Ridgley, RM
    Rasooly, A
    Wright, SC
    Larrick, JW
    Rasooly, R
    Carlson, JR
    [J]. SCIENCE, 1998, 280 (5362) : 438 - 440
  • [10] Regulation of Staphylococcus aureus pathogenesis via target of RNAIII-activating protein (TRAP)
    Balaban, N
    Goldkorn, T
    Gov, Y
    Hirshberg, M
    Koyfman, N
    Matthews, HR
    Nhan, RT
    Singh, B
    Uziel, O
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (04) : 2658 - 2667