WDR5 Expression Is Prognostic of Breast Cancer Outcome

被引：32

作者：

Dai, Xiaofeng ^{[1
,2
]}

Guo, Wenwen ^{[1
,2
]}

Zhan, Chunjun ^{[1
,2
]}

Liu, Xiuxia ^{[1
,2
]}

Bai, Zhonghu ^{[1
,2
]}

Yang, Yankun ^{[1
,2
]}

机构：

[1] Jiangnan Univ, Sch Biotechnol, Wuxi, Peoples R China

[2] Jiangnan Univ, Natl Engn Lab Cereal Fermentat Technol, Wuxi, Peoples R China

来源：

PLOS ONE | 2015年 / 10卷 / 09期

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

ESTROGEN-RECEPTOR; GENE-EXPRESSION; CHROMATIN; PROSTATE; MUTATION; IDENTIFICATION; TRANSCRIPTION; METHYLATION;

D O I：

10.1371/journal.pone.0124964

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

WDR5 is a core component of the human mixed lineage leukemia-2 complex, which plays central roles in ER positive tumour cells and is a major driver of androgen-dependent prostate cancer cell proliferation. Given the similarities between breast and prostate cancers, we explore the potential prognostic value of WDR5 gene expression on breast cancer survival. Our findings reveal that WDR5 over-expression is associated with poor breast cancer clinical outcome in three gene expression data sets and BreastMark. The eQTL analysis reveals 130 trans-eQTL SNPs whose genes mapped with statistical significance are significantly associated with patient survival. These genes together with WDR5 are enriched with "cellular development, gene expression, cell cycle" signallings. Knocking down WDR5 in MCF7 dramatically decreases cell viability, but does not alter tumour cell response to doxorubicin. Our study reveals the prognostic value of WDR5 expression in breast cancer which is under long-range regulation of genes involved in cell cycle, and anthracycline could be coupled with treatments targeting WDR5 once such a regimen is available.

引用

页数：15

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