Click inspired synthesis of p-tert-butyl calix[4]arene tethered benzotriazolyl dendrimers and their evaluation as anti-bacterial and anti-biofilm agents

被引：19

作者：

Agrahari, Anand K. ^{[1
]}

Singh, Ashish K. ^{[2
]}

Singh, Anoop S. ^{[1
]}

Singh, Mala ^{[1
]}

Maji, Pathik ^{[3
]}

Yadav, Shivangi ^{[2
]}

Rajkhowa, Sanchayita ^{[4
]}

Prakash, Pradyot ^{[2
]}

Tiwari, Vinod K. ^{[1
]}

机构：

[1] Banaras Hindu Univ, Ctr Adv Study, Inst Sci, Dept Chem, Varanasi 221005, Uttar Pradesh, India

[2] Banaras Hindu Univ, Inst Med Sci, Dept Microbiol, Bacterial Biofilm & Drug Resistance Res Lab, Varanasi 221005, Uttar Pradesh, India

[3] Guru Ghasidas Univ, Dept Chem, Bilaspur 495009, India

[4] Jorhat Inst Sci & Technol, Dept Chem, Jorhat 785010, Assam, India

来源：

NEW JOURNAL OF CHEMISTRY | 2020年 / 44卷 / 44期

关键词：

BIOLOGICAL APPLICATIONS; CALIXARENE; CHEMISTRY; TRIAZOLE; INHIBITORS; NANOPARTICLES; CYCLOADDITION; CYTOTOXICITY; DERIVATIVES; SELECTIVITY;

D O I：

10.1039/d0nj02591g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Calixarenes with their three-dimensional structural architecture and ease of functionalization at the upper and/or lower rim are well-known for their plethora of applications in chemical, physical, biological and other disciplines. Herein, CuAAC click inspired p-tert-butylcalix[4]arene tethered benzotriazolyl dendrimers, for example, N-1, N-2 type 2-fold compound 6 and 7 'G(0)' and 6-fold compound 16 and 17 'G(1)' generation benzotriazolyl dendrimer, were devised and also evaluated for their therapeutic potential both in vitro and in vivo. The developed calix[4]arene tethered benzotriazolyl dendrimers have been characterized by standard spectroscopic analysis including NMR (H-1 and C-13), MS, and SEC. Among all the benzotriazolyl dendrimers developed, compound 7 was identified as the effective one which provided potential anti-bacterial and anti-biofilm activities against drug-resistant and slime producing organisms without imparting cytotoxicity to the eukaryotic systems.

引用

页码：19300 / 19313

页数：14

共 84 条

[11] Antibiofilm effect enhanced by modification of 1,2,3-triazole and palladium nanoparticles on polysulfone membranes [J].