An endogenous aryl hydrocarbon receptor ligand inhibits proliferation and migration of human ovarian cancer cells

被引：71
作者：
Wang, Kai [1 ,2 ]
Li, Yan [2 ]
Jiang, Yi-Zhou [2 ]
Dai, Cai-Feng [2 ,3 ]
Patankar, Manish S. [2 ]
Song, Jia-Sheng [4 ]
Zheng, Jing [2 ,5 ]
机构：
[1] Tongji Univ, Sch Med, Shanghai Matern & Infant Hosp 1, Shanghai 200040, Peoples R China
[2] Univ Wisconsin, Dept Obstet & Gynecol, Madison, WI 53715 USA
[3] Shandong Univ, Qilu Hosp, Jinan 250012, Shandong, Peoples R China
[4] AhR Pharmaceut Inc, Madison, WI 53719 USA
[5] Guangdong Med Coll, Affiliated Hosp, Dept Cardiovasc Med, Zhanjiang 524001, Guangdong, Peoples R China
来源：
CANCER LETTERS | 2013年 / 340卷 / 01期
基金：
美国国家卫生研究院; 中国国家自然科学基金;
关键词：
ITE; Aryl hydrocarbon receptor; Ovarian cancer cells; Growth; BREAST-CANCER; EXPRESSION; DIOXIN; ESTROGEN; ACTIVATION; ALPHA; MECHANISMS; MORTALITY; CARCINOMA; SUBTYPES;
D O I：
10.1016/j.canlet.2013.06.026
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor mediates many biological processes. Herein, we investigated if 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE, an endogenous AhR ligand) regulated proliferation and migration of human ovarian cancer cells via AhR. We found that AhR was widely present in many histotypes of ovarian cancer tissues. ITE suppressed OVCAR-3 cell proliferation and SKOV-3 cell migration in vitro, which were blocked by AhR knockdown. ITE also suppressed OVCAR-3 cell growth in mice. These data suggest that the ITE might potentially be used for therapeutic intervention for at least a subset of human ovarian cancer. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：63 / 71
页数：9
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