WARP is a new member of the von Willebrand factor A-domain superfamily of extracellular matrix proteins

被引：32

作者：

Fitzgerald, J ^{[1
]}

Ting, ST

Bateman, JF

机构：

[1] Univ Melbourne, Royal Childrens Hosp, Cell & Matrix Biol Res Unit, Murdoch Childrens Res Inst, Parkville, Vic 3052, Australia

[2] Univ Melbourne, Royal Childrens Hosp, Dept Paediat, Parkville, Vic 3052, Australia

来源：

FEBS LETTERS | 2002年 / 517卷 / 1-3期

基金：

英国医学研究理事会;

关键词：

von Willebrand factor A-domain; fibronectin type III repeat; extracellular matrix;

D O I：

10.1016/S0014-5793(02)02579-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report a new member of the von Willebrand factor A-domain protein superfamily, WARP (for von Willebrand factor A-domain-related protein). The full-length mouse WARP cDNA is 2.3 kb in size and predicts a protein of 415 amino acids which contains a signal sequence, a VA-like domain, two fibronectin type III-like repeats, and a short proline- and arginine-rich segment. WARP mRNA was expressed predominantly in chondrocytes and in vitro expression experiments in transfected 293 cells indicated that WARP is a secreted glycoprotein that forms disulphide-bonded oligomers. We conclude that WARP is a new member of the con Willebrand factor A-domain (VA-domain) superfamily of extracellular matrix proteins which may play a role in cartilage structure and function. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：61 / 66

页数：6

共 43 条

[1] ABNORMAL TYPE-I COLLAGEN-METABOLISM BY CULTURED FIBROBLASTS IN LETHAL PERINATAL OSTEOGENESIS IMPERFECTA [J].

BATEMAN, JF ;

MASCARA, T ;

CHAN, D ;

COLE, WG .

BIOCHEMICAL JOURNAL, 1984, 217 (01) :103-115

[2] The C-terminal domain of cartilage matrix protein assembles into a triple-stranded alpha-helical coiled-coil structure [J].

Beck, K ;

Gambee, JE ;

Bohan, CA ;

Bachinger, HP .

JOURNAL OF MOLECULAR BIOLOGY, 1996, 256 (05) :909-923

[3] The von Willebrand factor A3 domain does not contain a metal ion-dependent adhesion site motif [J].

Bienkowska, J ;

Cruz, M ;

Atiemo, A ;

Handin, R ;

Liddington, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (40) :25162-25167

[4] Structure and distribution of modules in extracellular proteins [J].

Bork, P ;

Downing, AK ;

Kieffer, B ;

Campbell, ID .

QUARTERLY REVIEWS OF BIOPHYSICS, 1996, 29 (02) :119-167

[5] Site-directed mutagenesis of human type X collagen - Expression of alpha 1(X) NC1, NC2, and helical mutations in vitro and in transfected cells [J].

Chan, D ;

Weng, YM ;

Hocking, AM ;

Golub, S ;

McQuillan, DJ ;

Bateman, JF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (23) :13566-13572

[6]

CHAN D, 1993, J BIOL CHEM, V268, P15238

[7] Assembly of a novel cartilage matrix protein filamentous network: Molecular basis of differential requirement of von Willebrand factor A domains [J].

Chen, Q ;

Zhang, Y ;

Johnson, DM ;

Goetinck, PF .

MOLECULAR BIOLOGY OF THE CELL, 1999, 10 (07) :2149-2162

[8] SINGLE-STEP METHOD OF RNA ISOLATION BY ACID GUANIDINIUM THIOCYANATE PHENOL CHLOROFORM EXTRACTION [J].

CHOMCZYNSKI, P ;

SACCHI, N .

ANALYTICAL BIOCHEMISTRY, 1987, 162 (01) :156-159

[9] MOSAIC STRUCTURE OF GLOBULAR DOMAINS IN THE HUMAN TYPE-VI COLLAGEN ALPHA-3 CHAIN - SIMILARITY TO VONWILLEBRAND-FACTOR, FIBRONECTIN, ACTIN, SALIVARY PROTEINS AND APROTININ TYPE PROTEASE INHIBITORS [J].

CHU, ML ;

ZHANG, RZ ;

PAN, TC ;

STOKES, D ;

CONWAY, D ;

KUO, HJ ;

GLANVILLE, R ;

MAYER, U ;

MANN, K ;

DEUTZMANN, R ;

TIMPL, R .

EMBO JOURNAL, 1990, 9 (02) :385-393

[10] SEQUENCE-ANALYSIS OF ALPHA-1(VI) AND ALPHA-2(VI) CHAINS OF HUMAN TYPE-VI COLLAGEN REVEALS INTERNAL TRIPLICATION OF GLOBULAR DOMAINS SIMILAR TO THE A-DOMAINS OF VONWILLEBRAND-FACTOR AND 2 ALPHA-2(VI) CHAIN VARIANTS THAT DIFFER IN THE CARBOXY TERMINUS [J].

CHU, ML ;

PAN, TC ;

CONWAY, D ;

KUO, HJ ;

GLANVILLE, RW ;

TIMPL, R ;

MANN, K ;

DEUTZMANN, R .

EMBO JOURNAL, 1989, 8 (07) :1939-1946

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