The IKK-related kinases: from innate immunity to oncogenesis

被引：158
作者：
Clement, Jean-Francois [1 ,2 ]
Meloche, Sylvain [3 ,4 ,5 ]
Servant, Marc J. [1 ,2 ]
机构：
[1] Univ Montreal, Fac Pharm, Montreal, PQ H3C 3J7, Canada
[2] Univ Montreal, Grp Rech Univ Medicament, Montreal, PQ H3C 3J7, Canada
[3] Univ Montreal, Inst Rech Immunol & Cancerol, Montreal, PQ H3C 3J7, Canada
[4] Univ Montreal, Dept Pharmacol, Montreal, PQ H3C 3J7, Canada
[5] Univ Montreal, Dept Mol Biol, Montreal, PQ H3C 3J7, Canada
来源：
CELL RESEARCH | 2008年 / 18卷 / 09期
基金：
加拿大健康研究院;
关键词：
cancer; IKKi; TBK1; cytokines; NF-kappa B; interferon regulatory factor; inflammation;
D O I：
10.1038/cr.2008.273
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Over the past four years, the field of the innate immune response has been highly influenced by the discovery of the I kappa B kinase (IKK)-related kinases, TANK Binding Kinase 1 (TBK1) and IKKi, which regulate the activity of interferon regulatory factor (IRF)-3/IRF-7 and NF-kappa B transcription factors. More recently, additional essential components of the signaling pathways that activate these IKK homologues have been discovered. These include the RNA helicases RIGi and MDA5, and the downstream mitochondrial effector known as CARDIF/MAVS/VISA/IPS-1. In addition to their essential functions in controlling the innate immune response, recent studies have highlighted a role of these kinases in cell proliferation and oncogenesis. The canonical IKKs are well recognized to be a bridge linking chronic inflammation to cancer. New findings now suggest that the IKK-related kinases TBK1 and IKKi also participate in signaling pathways that impact on cell transformation and tumor progression. This review will therefore summarize and discuss the role of TBK1 and IKKi in cellular transformation and oncogenesis by focusing on their regulation and substrate specificity.
引用
收藏
页码：889 / 899
页数：11
相关论文
共 118 条
  • [11] Negative regulation of the alpha interferon-induced antiviral response by the Ras/Raf/MEK pathway
    Battcock, SA
    Collier, TW
    Zu, D
    Hirasawa, K
    [J]. JOURNAL OF VIROLOGY, 2006, 80 (09) : 4422 - 4430
  • [12] Involvement of the IκB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation
    Bibeau-Poirier, Annie
    Gravel, Simon-Pierre
    Clement, Jean-Francois
    Rolland, Sebastien
    Rodier, Genevieve
    Coulombe, Philippe
    Hiscott, John
    Grandvaux, Nathalie
    Meloche, Sylvain
    Servant, Marc J.
    [J]. JOURNAL OF IMMUNOLOGY, 2006, 177 (08) : 5059 - 5067
  • [13] Integrative genomic approaches identify IKBKE as a breast cancer oncogene
    Boehm, Jesse S.
    Zhao, Jean J.
    Yao, Jun
    Kim, So Young
    Firestein, Ron
    Dunn, Ian F.
    Sjostrom, Sarah K.
    Garraway, Levi A.
    Weremowicz, Stanislawa
    Richardson, Andrea L.
    Greulich, Heidi
    Stewart, Carly J.
    Mulvey, Laura A.
    Shen, Rhine R.
    Ambrogio, Lauren
    Hirozane-Kishikawa, Tomoko
    Hill, David E.
    Vidal, Marc
    Meyerson, Matthew
    Grenier, Jennifer K.
    Hinkle, Greg
    Root, David E.
    Roberts, Thomas M.
    Lander, Eric S.
    Polyak, Kornelia
    Hahn, William C.
    [J]. CELL, 2007, 129 (06) : 1065 - 1079
  • [14] p53 induces NF-κB activation by an IκB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1
    Bohuslav, J
    Chen, LF
    Kwon, H
    Mu, YJ
    Greene, WC
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (25) : 26115 - 26125
  • [15] Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-κB-dependent gene transcription
    Bonnard, M
    Mirtsos, C
    Suzuki, S
    Graham, K
    Huang, JN
    Ng, M
    Itié, A
    Wakeham, A
    Shahinian, A
    Henzel, WJ
    Elia, AJ
    Shillinglaw, W
    Mak, TW
    Cao, ZD
    Yeh, WC
    [J]. EMBO JOURNAL, 2000, 19 (18) : 4976 - 4985
  • [16] STATs in oncogenesis
    Bowman, T
    Garcia, R
    Turkson, J
    Jove, R
    [J]. ONCOGENE, 2000, 19 (21) : 2474 - 2488
  • [17] The role of STATs in transcriptional control and their impact on cellular function
    Bromberg, J
    Darnell, JE
    [J]. ONCOGENE, 2000, 19 (21) : 2468 - 2473
  • [18] Constitutive and interleukin-1-inducible phosphorylation of p65 NF-κB at serine 536 is mediated by multiple protein kinases including IκB kinase (IKK)-α, IKKβ, IKKε, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription
    Buss, H
    Dörrie, A
    Schmitz, ML
    Hoffmann, E
    Resch, K
    Kracht, M
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (53) : 55633 - 55643
  • [19] Regulatory serine residues mediate phosphorylation-dependent and phosphorylation-independent activation of interferon regulatory factor 7
    Caillaud, A
    Hovanessian, AG
    Levy, DE
    Marié, IJ
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (18) : 17671 - 17677
  • [20] Ral GTPases: corrupting the exocyst in cancer cells
    Camonis, JH
    White, MA
    [J]. TRENDS IN CELL BIOLOGY, 2005, 15 (06) : 327 - 332
12345678910