Regulation and pro-inflammatory function of interleukin-17 family cytokines

被引：96

作者：

Dong, Chen ^{[1
]}

机构：

[1] Univ Texas Houston, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA

来源：

IMMUNOLOGICAL REVIEWS | 2008年 / 226卷

基金：

美国国家卫生研究院;

关键词：

IL-17; IL-17F; IL-25; inflammation; helper T cells; autoimmune diseases;

D O I：

10.1111/j.1600-065X.2008.00709.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The interleukin-17 (IL-17) family consists of six cytokines in mammals. Among them, IL-17 and IL-17F are expressed by a novel subset of CD4(+) helper T cells and play critical function in inflammation and autoimmunity. IL-17E, also called IL-25, has been associated with allergic responses. Here, I summarize recent work by my laboratory as well as other investigators in understanding the regulation and function of these three cytokines. From these studies, IL-17 family cytokines may serve as novel targets for pharmaceutical intervention of immune and inflammatory diseases.

引用

页码：80 / 86

页数：7

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