The Relationship Between Water Structure and Blood Compatibility in Poly(2-methoxyethyl Acrylate) (PMEA) Analogues

被引：85

作者：

Sato, Kazuhiro ^{[1
]}

Kobayashi, Shingo ^{[1
,3
]}

Kusakari, Miho ^{[1
]}

Watahiki, Shogo ^{[1
]}

Oikawa, Masahiko ^{[1
]}

Hoshiba, Takashi ^{[1
,2
]}

Tanaka, Masaru ^{[1
,3
]}

机构：

[1] Yamagata Univ, Grad Sch Sci & Engn, Dept Biochem Engn, Yonezawa, Yamagata 9928510, Japan

[2] Natl Inst Mat Sci, Int Ctr Mat Nanoarchitecton MANA, Tsukuba, Ibaraki 3050044, Japan

[3] Kyushu Univ, Inst Mat Chem & Engn, Nishi Ku, Fukuoka 8190395, Japan

来源：

MACROMOLECULAR BIOSCIENCE | 2015年 / 15卷 / 09期

关键词：

biomaterial; blood compatibility; intermediate water; protein adsorption; water structure; POLY(ETHYLENE GLYCOL); PROTEIN ADSORPTION; PLATELET-ADHESION; PLASMA-PROTEINS; DRUG-DELIVERY; SURFACE; POLYMERS; MECHANISM; POLYMERIZATION; NANOCARRIERS;

D O I：

10.1002/mabi.201500078

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Six types of poly(2-methoxyethyl acrylate) (PMEA) analogues were synthesized and the water structure in the hydrated polymers was characterized using differential scanning calorimetry (DSC). The hydrated PMEA analogues exhibited the different amounts of intermediate water. Non-thrombogenicity evaluation was performed on PMEA analogues for platelet adhesion and protein adsorption. Platelet adhesion was suppressed on PMEA analogues. In addition, the protein adsorption and deformation were suppressed by increasing the amount of intermediate water. This study demonstrates that the amount of intermediate water might play a key role in expressing the blood compatibility of polymeric materials.

引用

页码：1296 / 1303

页数：8

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