Intestinal epithelial cells as mediators of the commensal-host immune crosstalk

被引：123

作者：

Goto, Yoshiyuki ^{[1
]}

Ivanov, Ivaylo I. ^{[1
]}

机构：

[1] Columbia Univ, Med Ctr, Dept Microbiol & Immunol, New York, NY 10032 USA

来源：

IMMUNOLOGY AND CELL BIOLOGY | 2013年 / 91卷 / 03期

基金：

日本学术振兴会;

关键词：

Intestinal epithelial cells; IEC; commensal bacteria; SFB; Th17; Treg; SEGMENTED FILAMENTOUS BACTERIA; FOLLICLE-ASSOCIATED EPITHELIUM; INFLAMMATORY-BOWEL-DISEASE; INNATE LYMPHOID-CELLS; DELTA-T-CELLS; DENDRITIC CELLS; INTRAEPITHELIAL LYMPHOCYTES; NATURAL-KILLER; LAMINA PROPRIA; MICROBIAL COLONIZATION;

D O I：

10.1038/icb.2012.80

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Commensal bacteria regulate the homeostasis of host effector immune cell subsets. The mechanisms involved in this commensal host crosstalk are not well understood. Intestinal epithelial cells (IECs) not only create a physical barrier between the commensals and immune cells in host tissues, but also facilitate interactions between them. Perturbations of epithelial homeostasis or function lead to the development of intestinal disorders such as inflammatory bowel diseases (IBD) and intestinal cancer. IECs receive signals from commensals and produce effector immune molecules. IECs also affect the function of immune cells in the lamina propria. Here we discuss some of these properties of IECs that define them as innate immune cells. We focus on how IECs may integrate and transmit signals from individual commensal bacteria to mucosal innate and adaptive immune cells for the establishment of the unique mucosal immunological equilibrium. Immunology and Cell Biology (2013) 91, 204-214; doi:10.1038/icb.2012.80; published online 15 January 2013

引用

页码：204 / 214

页数：11

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