Impact of cellular autophagy on viruses: Insights from hepatitis B virus and human retroviruses

被引：47

作者：

Tang, Sai-Wen ^{[1
]}

Ducroux, Aurelie ^{[2
]}

Jeang, Kuan-Teh ^{[1
]}

Neuveut, Christine ^{[2
]}

机构：

[1] NIAID, Mol Virol Sect, Mol Microbiol Lab, NIH, Bethesda, MD 20892 USA

[2] Inst Pasteur, Lab Hepacivirus & Innate Immun, F-75015 Paris, France

来源：

JOURNAL OF BIOMEDICAL SCIENCE | 2012年 / 19卷

关键词：

NF-KAPPA-B; PROTEIN CONJUGATION SYSTEM; HIV-1; REPLICATION; C VIRUS; SUPPRESSOR ACTIVITY; REGULATE AUTOPHAGY; T-LYMPHOCYTES; CELLS; RESTRICTION; INHIBITION;

D O I：

10.1186/1423-0127-19-92

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Autophagy is a protein degradative process important for normal cellular metabolism. It is apparently used also by cells to eliminate invading pathogens. Interestingly, many pathogens have learned to subvert the cell's autophagic process. Here, we review the interactions between viruses and cells in regards to cellular autophagy. Using findings from hepatitis B virus and human retroviruses, HIV-1 and HTLV-1, we discuss mechanisms used by viruses to usurp cellular autophagy in ways that benefit viral replication.

引用

页数：11

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