Sumo and the cellular stress response

被引:143
作者
Enserink, Jorrit M. [1 ]
机构
[1] Oslo Univ Hosp, Inst Microbiol, N-0027 Oslo, Norway
关键词
Sumo; Stress response; Transcription; DNA damage response; ER stress; Viral infections; Nutrient stress; SIMs; PROTEOME-WIDE IDENTIFICATION; KAPPA-B ACTIVATION; E3 LIGASE ACTIVITY; TRANSCRIPTION FACTOR; GLOBAL ANALYSIS; SACCHAROMYCES-CEREVISIAE; SUBSTRATE RECOGNITION; BINDING MOTIF; CROSS-TALK; UBIQUITIN;
D O I
10.1186/s13008-015-0010-1
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The ubiquitin family member Sumo has important functions in many cellular processes including DNA repair, transcription and cell division. Numerous studies have shown that Sumo is essential for maintaining cell homeostasis when the cell encounters endogenous or environmental stress, such as osmotic stress, hypoxia, heat shock, genotoxic stress, and nutrient stress. Regulation of transcription is a key component of the Sumo stress response, and multiple mechanisms have been described by which Sumo can regulate transcription. Although many individual substrates have been described that are sumoylated during the Sumo stress response, an emerging concept is modification of entire complexes or pathways by Sumo. This review focuses on the function and regulation of Sumo during the stress response.
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页数:13
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