Interaction of Interleukin-16 Genotypes With Betel Quid Chewing Behavior on Oral Cancer in Taiwan

被引:10
作者
Shih, Liang-Chun [1 ,2 ,3 ]
Chang, Wen-Shin [1 ,2 ]
Lee, Hsu-Tung [4 ,5 ]
Wang, Yun-Chi [1 ,2 ]
Wang, Zhi-Hong [6 ]
Chao, Che-Yi [6 ]
Yu, Chien-Chih [2 ,7 ]
Lin, Hui-Yi [7 ]
Shen, Te-Chun [2 ]
Kuo, Chien-Chung [2 ]
Tsai, Chia-Wen [1 ,2 ]
Bau, Da-Tian [1 ,2 ,8 ]
机构
[1] China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan
[2] China Med Univ Hosp, Dept Med Res, Terry Fox Canc Res Lab, 2 Yuh Der Rd, Taichung 404, Taiwan
[3] China Med Univ Hosp, Dept Otolaryngol, Taichung, Taiwan
[4] Taichung Vet Gen Hosp, Canc Prevent Ctr, Taichung, Taiwan
[5] Taichung Vet Gen Hosp, Neurol Inst, Dept Neurosurg, Taichung, Taiwan
[6] Asia Univ, Dept Food Nutr & Hlth Biotechnol, Taichung, Taiwan
[7] China Med Univ, Sch Pharm, Taichung, Taiwan
[8] Asia Univ, Dept Bioinformat & Med Engn, Taichung, Taiwan
来源
IN VIVO | 2020年 / 34卷 / 04期
关键词
Betel quid chewing; genotype; interleukin-16; oral cancer; single nucleotide polymorphism; Taiwan; GENETIC-POLYMORPHISM; PROMOTER GENOTYPES; MULTIPLE-MYELOMA; SERUM-LEVELS; SUSCEPTIBILITY; ASSOCIATION; EXPRESSION; METASTASIS; ACTIVATION; RISK;
D O I
10.21873/invivo.11969
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Background/Aim: Interleukin-16 (IL-16) is reported to play an important role in inflammation, carcinogenesis and tumoricidal processes, however, the contribution of IL-16 genotype to oral carcinogenesis is still largely unrevealed. Thus, the study aimed to investigate the contribution of IL-16 genotypes to Taiwan oral cancer risk. Materials and Methods: The genotypes of IL-16 rs4778889, rs11556218, and rs4072111 were revealed among 958 oral cancer cases and 958 control subjects by polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). Results: First, the distributions of genotypic (p=0.0004) and allelic (p=0.0001) frequencies of IL-16 rs11556218 were significantly different between the case and control groups. In detail, the frequencies of IL-16 rs11556218 TG and GG were 28.1 and 5.8%, respectively, among oral cancer patients, significantly higher compared to those among controls (25.0% and 2.7%, respectively). Second, no difference was observed regarding IL-16 rs4778889 or IL-16 rs4072111. Last, there was a synergistic effect of betel quid chewing behavior and risky IL-16 rs11556218 genotype on oral cancer risk. Conclusion: The study indicates that the IL-16 rs11556218 G allele synergistically interacts with betel quid chewing behavior, contributing to increased risk of oral cancer in Taiwanese.
引用
收藏
页码:1759 / 1764
页数:6
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