Interaction of Interleukin-16 Genotypes With Betel Quid Chewing Behavior on Oral Cancer in Taiwan

被引：10

作者：

Shih, Liang-Chun ^{[1
,2
,3
]}

Chang, Wen-Shin ^{[1
,2
]}

Lee, Hsu-Tung ^{[4
,5
]}

Wang, Yun-Chi ^{[1
,2
]}

Wang, Zhi-Hong ^{[6
]}

Chao, Che-Yi ^{[6
]}

Yu, Chien-Chih ^{[2
,7
]}

Lin, Hui-Yi ^{[7
]}

Shen, Te-Chun ^{[2
]}

Kuo, Chien-Chung ^{[2
]}

Tsai, Chia-Wen ^{[1
,2
]}

Bau, Da-Tian ^{[1
,2
,8
]}

机构：

[1] China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan

[2] China Med Univ Hosp, Dept Med Res, Terry Fox Canc Res Lab, 2 Yuh Der Rd, Taichung 404, Taiwan

[3] China Med Univ Hosp, Dept Otolaryngol, Taichung, Taiwan

[4] Taichung Vet Gen Hosp, Canc Prevent Ctr, Taichung, Taiwan

[5] Taichung Vet Gen Hosp, Neurol Inst, Dept Neurosurg, Taichung, Taiwan

[6] Asia Univ, Dept Food Nutr & Hlth Biotechnol, Taichung, Taiwan

[7] China Med Univ, Sch Pharm, Taichung, Taiwan

[8] Asia Univ, Dept Bioinformat & Med Engn, Taichung, Taiwan

来源：

IN VIVO | 2020年 / 34卷 / 04期

关键词：

Betel quid chewing; genotype; interleukin-16; oral cancer; single nucleotide polymorphism; Taiwan; GENETIC-POLYMORPHISM; PROMOTER GENOTYPES; MULTIPLE-MYELOMA; SERUM-LEVELS; SUSCEPTIBILITY; ASSOCIATION; EXPRESSION; METASTASIS; ACTIVATION; RISK;

D O I：

10.21873/invivo.11969

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background/Aim: Interleukin-16 (IL-16) is reported to play an important role in inflammation, carcinogenesis and tumoricidal processes, however, the contribution of IL-16 genotype to oral carcinogenesis is still largely unrevealed. Thus, the study aimed to investigate the contribution of IL-16 genotypes to Taiwan oral cancer risk. Materials and Methods: The genotypes of IL-16 rs4778889, rs11556218, and rs4072111 were revealed among 958 oral cancer cases and 958 control subjects by polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). Results: First, the distributions of genotypic (p=0.0004) and allelic (p=0.0001) frequencies of IL-16 rs11556218 were significantly different between the case and control groups. In detail, the frequencies of IL-16 rs11556218 TG and GG were 28.1 and 5.8%, respectively, among oral cancer patients, significantly higher compared to those among controls (25.0% and 2.7%, respectively). Second, no difference was observed regarding IL-16 rs4778889 or IL-16 rs4072111. Last, there was a synergistic effect of betel quid chewing behavior and risky IL-16 rs11556218 genotype on oral cancer risk. Conclusion: The study indicates that the IL-16 rs11556218 G allele synergistically interacts with betel quid chewing behavior, contributing to increased risk of oral cancer in Taiwanese.

引用

页码：1759 / 1764

页数：6

共 31 条

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