Aspects of astrocyte energy metabolism, amino acid neurotransmitter homoeostasis and metabolic compartmentation

被引：61

作者：

Kreft, Marko ^{[2
,3
]}

Bak, Lasse K. ^{[1
]}

Waagepetersen, Helle S. ^{[1
]}

Schousboe, Arne ^{[1
]}

机构：

[1] Univ Copenhagen, Fac Hlth & Med Sci, Dept Drug Design & Pharmacol, DK-2100 Copenhagen, Denmark

[2] Univ Ljubljana, LN MCP, Fac Med, Inst Pathophysiol, Ljubljana 61000, Slovenia

[3] Univ Ljubljana, CPAE, Biotech Fac, Dept Biol, Ljubljana 61000, Slovenia

来源：

ASN NEURO | 2012年 / 4卷 / 03期

关键词：

amino acid; astrocyte; compartmentation; energy; metabolism; BLOOD-BRAIN-BARRIER; GLYCOGEN-SYNTHASE KINASE-3; GLUCOSE-TRANSPORTER GLUT1; BERGMANN GLIAL-CELLS; PRIMARY CULTURES; RAT-BRAIN; NEURONAL-ACTIVITY; OXIDATIVE-METABOLISM; IN-VIVO; GLUTAMATE TRANSPORTERS;

D O I：

10.1042/AN20120007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Astrocytes are key players in brain function; they are intimately involved in neuronal signalling processes and their metabolism is tightly coupled to that of neurons. In the present review, we will be concerned with a discussion of aspects of astrocyte metabolism, including energy-generating pathways and amino acid homoeostasis. A discussion of the impact that uptake of neurotransmitter glutamate may have on these pathways is included along with a section on metabolic compartmentation.

引用

页码：187 / 199

页数：13

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